OBJECTIVES: To evaluate whether changes in BOLD signal intensities following hyperoxygenation are related to intrauterine growth restriction (IUGR) in a rat model. METHODS: IUGR was induced in pregnant rats by ligating the left vascular uterine pedicle at day 16 of gestation. BOLD MR imaging using a balanced steady-state free-precession (balanced-SSFP) sequence on a 1.5-T system was performed on day 19. Signal intensities (SI) before and after maternal hyperoxygenation were compared in the maternal liver and in control and growth-restricted foetoplacental units (FPUs). RESULTS: Maternal hyperoxygenation resulted in a significant increase in SI in all regions of interest (P < 0.05) in the 18 rats. In the control group, the SI (mean ± SD) increased by 21 % ± 15 in placentas (n = 74) and 13 % ± 8.5 in foetuses (n = 53). In the IUGR group, the increase was significantly lower: 6.5 % ± 4 in placentas (n = 36) and 7 %± 5.5 in foetuses (n = 34) (P < 0.05). CONCLUSION: BOLD MRI allows non-invasive assessment of the foetoplacental response to maternal hyperoxygenation in the rat and demonstrates its alteration in an IUGR model. This imaging method may provide a useful adjunct for the early diagnosis, evaluation, and management of human IUGR. KEY POINTS: • Intra-uterine growth restriction is an important cause of perinatal morbidity and mortality. • Blood oxygen level-dependent MRI non-invasively assesses foetoplacental response to maternal hyperoxygenation. • In the rat, foetoplacental response to maternal hyperoxygenation is altered in IUGR. • Functional MRI may help to assess human IUGR.
OBJECTIVES: To evaluate whether changes in BOLD signal intensities following hyperoxygenation are related to intrauterine growth restriction (IUGR) in a rat model. METHODS: IUGR was induced in pregnant rats by ligating the left vascular uterine pedicle at day 16 of gestation. BOLD MR imaging using a balanced steady-state free-precession (balanced-SSFP) sequence on a 1.5-T system was performed on day 19. Signal intensities (SI) before and after maternal hyperoxygenation were compared in the maternal liver and in control and growth-restricted foetoplacental units (FPUs). RESULTS: Maternal hyperoxygenation resulted in a significant increase in SI in all regions of interest (P < 0.05) in the 18 rats. In the control group, the SI (mean ± SD) increased by 21 % ± 15 in placentas (n = 74) and 13 % ± 8.5 in foetuses (n = 53). In the IUGR group, the increase was significantly lower: 6.5 % ± 4 in placentas (n = 36) and 7 %± 5.5 in foetuses (n = 34) (P < 0.05). CONCLUSION: BOLD MRI allows non-invasive assessment of the foetoplacental response to maternal hyperoxygenation in the rat and demonstrates its alteration in an IUGR model. This imaging method may provide a useful adjunct for the early diagnosis, evaluation, and management of human IUGR. KEY POINTS: • Intra-uterine growth restriction is an important cause of perinatal morbidity and mortality. • Blood oxygen level-dependent MRI non-invasively assesses foetoplacental response to maternal hyperoxygenation. • In the rat, foetoplacental response to maternal hyperoxygenation is altered in IUGR. • Functional MRI may help to assess human IUGR.
Authors: David M Morris; John As Ross; Alexandra McVicar; Scott I K Semple; Paul Haggarty; Fiona J Gilbert; David R Abramovich; Norman Smith; Thomas W Redpath Journal: Physiol Meas Date: 2010-07-23 Impact factor: 2.833
Authors: Esra Abaci Turk; S Mazdak Abulnaga; Jie Luo; Jeffrey N Stout; Henry A Feldman; Ata Turk; Borjan Gagoski; Lawrence L Wald; Elfar Adalsteinsson; Drucilla J Roberts; Carolina Bibbo; Julian N Robinson; Polina Golland; P Ellen Grant; William H Barth Journal: Placenta Date: 2020-04-22 Impact factor: 3.481
Authors: Stefan Markovic; Anne Fages; Tangi Roussel; Ron Hadas; Alexander Brandis; Michal Neeman; Lucio Frydman Journal: Proc Natl Acad Sci U S A Date: 2018-02-14 Impact factor: 11.205
Authors: Esra Abaci Turk; Jeffrey N Stout; Christopher Ha; Jie Luo; Borjan Gagoski; Filiz Yetisir; Polina Golland; Lawrence L Wald; Elfar Adalsteinsson; Julian N Robinson; Drucilla J Roberts; William H Barth; P Ellen Grant Journal: Top Magn Reson Imaging Date: 2019-10
Authors: Lana Vasung; Esra Abaci Turk; Silvina L Ferradal; Jason Sutin; Jeffrey N Stout; Banu Ahtam; Pei-Yi Lin; P Ellen Grant Journal: Neuroimage Date: 2018-07-21 Impact factor: 6.556
Authors: Stephanie A Giza; Simran Sethi; Lauren M Smith; Mary-Ellen E T Empey; Lindsay E Morris; Charles A McKenzie Journal: J Dev Orig Health Dis Date: 2020-12-14 Impact factor: 2.401
Authors: Anne Sørensen; Marianne Sinding; David A Peters; Astrid Petersen; Jens B Frøkjær; Ole B Christiansen; Niels Uldbjerg Journal: Physiol Rep Date: 2015-10