Literature DB >> 23439586

Mineralocorticoid-receptor signalling in vascular smooth muscle.

Jing Wu1, Friedrich C Luft.   

Abstract

Human data suggest that eplerenone and spironolactone lowers blood pressure by mechanisms independent of the distal tubule. Now, a novel inducible conditional knockout model of the mineralocorticoid receptor (MR) in vascular smooth muscle cells (VSMCs) brings out understanding further.

Entities:  

Keywords:  LoxP; aldosterone; cre recombinase; hypertension; mineralocorticoid receptor

Mesh：

Substances：

Year:  2013        PMID： 23439586      PMCID： PMC4007112          DOI： 10.1093/ndt/gfs562

Source DB:  PubMed          Journal:  Nephrol Dial Transplant        ISSN： 0931-0509            Impact factor:   5.992


  5 in total

Review 1.  Aldosterone: its receptor, target genes, and actions.

Authors:  David Pearce; Aditi Bhargava; Timothy J Cole
Journal:  Vitam Horm       Date:  2003       Impact factor: 3.421

2.  Distinguishing the antihypertensive and electrolyte effects of eplerenone.

Authors:  D G Levy; R Rocha; J W Funder
Journal:  J Clin Endocrinol Metab       Date:  2004-06       Impact factor: 5.958

3.  Angiotensin II upregulates Ca(V)1.2 protein expression in cultured arteries via endothelial H(2)O(2) production.

Authors:  Wenze Wang; Li Pang; Philip Palade
Journal:  J Vasc Res       Date:  2010-07-14       Impact factor: 1.934

4.  Impairment of sodium balance in mice deficient in renal principal cell mineralocorticoid receptor.

Authors:  Caroline Ronzaud; Johannes Loffing; Markus Bleich; Norbert Gretz; Hermann-Josef Gröne; Günther Schütz; Stefan Berger
Journal:  J Am Soc Nephrol       Date:  2007-05-02       Impact factor: 10.121

5.  Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors.

Authors:  Amy McCurley; Paulo W Pires; Shawn B Bender; Mark Aronovitz; Michelle J Zhao; Daniel Metzger; Pierre Chambon; Michael A Hill; Anne M Dorrance; Michael E Mendelsohn; Iris Z Jaffe
Journal:  Nat Med       Date:  2012-09       Impact factor: 53.440
  5 in total

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