Literature DB >> 23439114

Broadening roles for FMRP: big news for big potassium (BK) channels.

Anis Contractor1.   

Abstract

FMRP is an RNA-binding protein that negatively regulates translation and which is lost in fragile X syndrome. In this issue of Neuron, Deng et al. (2013) demonstrate a novel translation-independent function for FMRP as a regulator of presynaptic BK channels that modulate the dynamics of neurotransmitter release.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Year:  2013        PMID： 23439114      PMCID： PMC3799860          DOI： 10.1016/j.neuron.2013.02.001

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  10 in total

1.  Local functions for FMRP in axon growth cone motility and activity-dependent regulation of filopodia and spine synapses.

Authors:  Laura N Antar; Chanxia Li; Honglai Zhang; Reed C Carroll; Gary J Bassell
Journal:  Mol Cell Neurosci       Date:  2006-05-02       Impact factor: 4.314

2.  FMRP regulates neurotransmitter release and synaptic information transmission by modulating action potential duration via BK channels.

Authors:  Pan-Yue Deng; Ziv Rotman; Jay A Blundon; Yongcheol Cho; Jianmin Cui; Valeria Cavalli; Stanislav S Zakharenko; Vitaly A Klyachko
Journal:  Neuron       Date:  2013-02-20       Impact factor: 17.173

Review 3.  New perspectives on the biology of fragile X syndrome.

Authors:  Tao Wang; Steven M Bray; Stephen T Warren
Journal:  Curr Opin Genet Dev       Date:  2012-02-28       Impact factor: 5.578

4.  Abnormal presynaptic short-term plasticity and information processing in a mouse model of fragile X syndrome.

Authors:  Pan-Yue Deng; David Sojka; Vitaly A Klyachko
Journal:  J Neurosci       Date:  2011-07-27       Impact factor: 6.167

5.  Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack.

Authors:  Maile R Brown; Jack Kronengold; Valeswara-Rao Gazula; Yi Chen; John G Strumbos; Fred J Sigworth; Dhasakumar Navaratnam; Leonard K Kaczmarek
Journal:  Nat Neurosci       Date:  2010-05-30       Impact factor: 24.884

6.  Regulation of neuronal excitability by interaction of fragile X mental retardation protein with slack potassium channels.

Authors:  Yalan Zhang; Maile R Brown; Callen Hyland; Yi Chen; Jack Kronengold; Matthew R Fleming; Andrea B Kohn; Leonid L Moroz; Leonard K Kaczmarek
Journal:  J Neurosci       Date:  2012-10-31       Impact factor: 6.167

7.  Presynaptic FMR1 genotype influences the degree of synaptic connectivity in a mosaic mouse model of fragile X syndrome.

Authors:  Jesse E Hanson; Daniel V Madison
Journal:  J Neurosci       Date:  2007-04-11       Impact factor: 6.167

Review 8.  Protein translation in synaptic plasticity: mGluR-LTD, Fragile X.

Authors:  Maggie W Waung; Kimberly M Huber
Journal:  Curr Opin Neurobiol       Date:  2009-05-04       Impact factor: 6.627

9.  The FXG: a presynaptic fragile X granule expressed in a subset of developing brain circuits.

Authors:  Sean B Christie; Michael R Akins; James E Schwob; Justin R Fallon
Journal:  J Neurosci       Date:  2009-02-04       Impact factor: 6.167

10.  FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism.

Authors:  Jennifer C Darnell; Sarah J Van Driesche; Chaolin Zhang; Ka Ying Sharon Hung; Aldo Mele; Claire E Fraser; Elizabeth F Stone; Cynthia Chen; John J Fak; Sung Wook Chi; Donny D Licatalosi; Joel D Richter; Robert B Darnell
Journal:  Cell       Date:  2011-07-22       Impact factor: 41.582
  10 in total
  3 in total

Review 1.  Altered Neuronal and Circuit Excitability in Fragile X Syndrome.

Authors:  Anis Contractor; Vitaly A Klyachko; Carlos Portera-Cailliau
Journal:  Neuron       Date:  2015-08-19       Impact factor: 17.173

2.  Activity-dependent regulation of release probability at excitatory hippocampal synapses: a crucial role of fragile X mental retardation protein in neurotransmission.

Authors:  Xiao-Sheng Wang; Chun-Zi Peng; Wei-Jun Cai; Jian Xia; Daozhong Jin; Yuqiao Dai; Xue-Gang Luo; Vitaly A Klyachko; Pan-Yue Deng
Journal:  Eur J Neurosci       Date:  2014-03-20       Impact factor: 3.386

Review 3.  Channelopathies in fragile X syndrome.

Authors:  Pan-Yue Deng; Vitaly A Klyachko
Journal:  Nat Rev Neurosci       Date:  2021-04-07       Impact factor: 34.870
  3 in total

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