| Literature DB >> 23438979 |
Julia C Schwarz1, Nuttakorn Baisaeng, Magdalena Hoppel, Monika Löw, Cornelia M Keck, Claudia Valenta.
Abstract
Coenzyme Q10 (CoQ10) acts as an antioxidant in the skin and is frequently contained in anti-aging products. In previous studies, it could be shown that nano-structured lipid carriers (NLC) with a size of about 230 nm are beneficial for the dermal delivery of CoQ10. They increased Q10 skin penetration when compared to equally sized nanoemulsion. In this study, ultra-small NLC were prepared with even smaller mean particles sizes of around 80 nm. The influence of this decrease of particle size was investigated in terms of skin permeation and penetration as well as physicochemical stability of the NLC. Improved dermal delivery of CoQ10 by ultra-small NLC could be achieved.Entities:
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Year: 2013 PMID： 23438979 DOI： 10.1016/j.ijpharm.2013.02.037
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875