Literature DB >> 23438818

Interleukin-1 receptor 2 keeps the lid on interleukin-1α.

Nelson C Di Paolo1, Dmitry M Shayakhmetov.   

Abstract

The molecular mechanisms that regulate functional activation of IL-1α remain elusive. In this issue of Immunity, Zheng et al. (2013) describe a molecular system implicating interleukin-1 receptor-2 (IL-1R2) as a principal cytosolic factor that controls functional IL-1α activation during necrosis.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Year:  2013        PMID： 23438818      PMCID： PMC3637128          DOI： 10.1016/j.immuni.2013.02.001

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  9 in total

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3.  Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α.

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4.  Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1.

Authors:  Olaf Gross; Amir S Yazdi; Christina J Thomas; Mark Masin; Leonhard X Heinz; Greta Guarda; Manfredo Quadroni; Stefan K Drexler; Jurg Tschopp
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5.  Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1 alpha.

Authors:  Y Kobayashi; K Yamamoto; T Saido; H Kawasaki; J J Oppenheim; K Matsushima
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6.  Identification of a key pathway required for the sterile inflammatory response triggered by dying cells.

Authors:  Chun-Jen Chen; Hajime Kono; Douglas Golenbock; George Reed; Shizuo Akira; Kenneth L Rock
Journal:  Nat Med       Date:  2007-06-17       Impact factor: 53.440

7.  The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor.

Authors:  B Mosley; D L Urdal; K S Prickett; A Larsen; D Cosman; P J Conlon; S Gillis; S K Dower
Journal:  J Biol Chem       Date:  1987-03-05       Impact factor: 5.157

8.  Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme.

Authors:  K Kuida; J A Lippke; G Ku; M W Harding; D J Livingston; M S Su; R A Flavell
Journal:  Science       Date:  1995-03-31       Impact factor: 47.728

Review 9.  Immunological and inflammatory functions of the interleukin-1 family.

Authors:  Charles A Dinarello
Journal:  Annu Rev Immunol       Date:  2009       Impact factor: 28.527
  9 in total
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Authors:  Nelson C Di Paolo; Lisa K Baldwin; Eric E Irons; Thalia Papayannopoulou; Stephen Tomlinson; Dmitry M Shayakhmetov
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Authors:  Elena Voronov; Shahar Dotan; Yakov Krelin; Xiaoping Song; Moshe Elkabets; Yaron Carmi; Peleg Rider; Marianna Romzova; Irena Kaplanov; Ron N Apte
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Review 4.  The role IL-1 in tumor-mediated angiogenesis.

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Journal:  Front Physiol       Date:  2014-03-28       Impact factor: 4.566

5.  NLRP3 Inflammasome Mediates Dormant Neutrophil Recruitment following Sterile Lung Injury and Protects against Subsequent Bacterial Pneumonia in Mice.

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6.  IL-1α and IL-1β-producing macrophages populate lung tumor lesions in mice.

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  6 in total

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