OBJECTIVE: To determine the prevalence and incidence of hypothyroidism, hyperthyroidism, and risk factors in patients with major depressive disorder (MDD). METHODS: The National Health Research Institute provided a database of 1,000,000 random subjects for health service studies. We identified subjects aged ≥18 years who had at least 1 service claim during 2005 with a primary diagnosis of MDD or with a primary or secondary diagnosis of hypothyroidism or hyperthyroidism. We also compared the incidence of hypothyroidism and hyperthyroidism among patients with MDD and the general population from 2006 through 2010. RESULTS: The prevalence of hypothyroidism in patients with MDD was higher than that in the general population (1.20% vs. 0.30%; odds ratio, 3.08; 95% confidence interval, 2.35-4.03) in 2005. The prevalence of hyperthyroidism was also higher in patients with MDD than in the general population (2.46% vs. 0.79%; odds ratio, 2.77; 95% confidence interval, 2.29-3.35) in 2005. The annual incidence of hypothyroidism was higher in patients with MDD than that in the general population (0.40% vs. 0.13%; risk ratio, 2.47; 95% confidence interval, 2.00-3.06). The annual incidence of hyperthyroidism was also higher in patients with MDD than that in the general population (0.72% vs. 0.32%; risk ratio, 2.06; 95% confidence interval, 1.75-2.43). CONCLUSIONS: Patients with MDD had a higher prevalence and a higher incidence of hypothyroidism or hyperthyroidism than the general population. Female sex was a risk factor for hypothyroidism and hyperthyroidism in MDD.
OBJECTIVE: To determine the prevalence and incidence of hypothyroidism, hyperthyroidism, and risk factors in patients with major depressive disorder (MDD). METHODS: The National Health Research Institute provided a database of 1,000,000 random subjects for health service studies. We identified subjects aged ≥18 years who had at least 1 service claim during 2005 with a primary diagnosis of MDD or with a primary or secondary diagnosis of hypothyroidism or hyperthyroidism. We also compared the incidence of hypothyroidism and hyperthyroidism among patients with MDD and the general population from 2006 through 2010. RESULTS: The prevalence of hypothyroidism in patients with MDD was higher than that in the general population (1.20% vs. 0.30%; odds ratio, 3.08; 95% confidence interval, 2.35-4.03) in 2005. The prevalence of hyperthyroidism was also higher in patients with MDD than in the general population (2.46% vs. 0.79%; odds ratio, 2.77; 95% confidence interval, 2.29-3.35) in 2005. The annual incidence of hypothyroidism was higher in patients with MDD than that in the general population (0.40% vs. 0.13%; risk ratio, 2.47; 95% confidence interval, 2.00-3.06). The annual incidence of hyperthyroidism was also higher in patients with MDD than that in the general population (0.72% vs. 0.32%; risk ratio, 2.06; 95% confidence interval, 1.75-2.43). CONCLUSIONS:Patients with MDD had a higher prevalence and a higher incidence of hypothyroidism or hyperthyroidism than the general population. Female sex was a risk factor for hypothyroidism and hyperthyroidism in MDD.
Authors: M Maciukiewicz; V S Marshe; A K Tiwari; T M Fonseka; N Freeman; J L Kennedy; S Rotzinger; J A Foster; S H Kennedy; D J Müller Journal: Pharmacogenomics J Date: 2017-07-11 Impact factor: 3.550
Authors: S L Carmichael; C Ma; S A Rasmussen; M L Cunningham; M L Browne; C Dosiou; E J Lammer; G M Shaw Journal: Am J Med Genet A Date: 2015-02-05 Impact factor: 2.802
Authors: Till Ittermann; Henry Völzke; Sebastian E Baumeister; Katja Appel; Hans J Grabe Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2015-03-17 Impact factor: 4.328
Authors: Juha Saltevo; Hannu Kautiainen; Pekka Mäntyselkä; Antti Jula; Sirkka Keinänen-Kiukaanniemi; Eeva Korpi-Hyövälti; Heikki Oksa; Timo Saaristo; Mauno Vanhala Journal: Clin Med Insights Endocrinol Diabetes Date: 2015-04-20