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Literature DB >> 23438057

Biological activities and corresponding SARs of andrographolide and its derivatives.

Abstract

In recent years, pharmaceutical chemists have synthesized large numbers of andrographolide derivatives, which bear important biological activities such as anti-inflammatory, antibacterial, antivirus, antitumor, antidiabetic, and antifeedant. Consequently, corresponding SARs were increasingly obvious. This paper aimed to review all the available literature in this field, highlighting the significant achievements on the structural modification and SARs of andrographolide and its derivatives.

Entities: Chemical

Mesh：

Substances：

Year: 2013 PMID： 23438057

Source DB: PubMed Journal: Mini Rev Med Chem ISSN： 1389-5575 Impact factor: 3.862

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Cited

11 in total

1. Adaptogenic potential of andrographolide: An active principle of the king of bitters (Andrographis paniculata).

Authors: Ajit Kumar Thakur; Shyam Sunder Chatterjee; Vikas Kumar
Journal: J Tradit Complement Med Date: 2014-12-19

2. Andrographolide sulfonate ameliorates lipopolysaccharide-induced acute lung injury in mice by down-regulating MAPK and NF-κB pathways.

Authors: Shuang Peng; Nan Hang; Wen Liu; Wenjie Guo; Chunhong Jiang; Xiaoling Yang; Qiang Xu; Yang Sun
Journal: Acta Pharm Sin B Date: 2016-03-22 Impact factor: 11.413

3. The antitumor effect of arsenic trioxide on hepatocellular carcinoma is enhanced by andrographolide.

Authors: Xuhua Duan; Tengfei Li; Xinwei Han; Jianzhuang Ren; Pengfei Chen; Hao Li; Shaojun Gong
Journal: Oncotarget Date: 2017-06-27

Review 4. Andrographolide, a New Hope in the Prevention and Treatment of Metabolic Syndrome.

Authors: Muhammad T Islam
Journal: Front Pharmacol Date: 2017-08-23 Impact factor: 5.810

5. Fabrication and in vitro/in vivo evaluation of amorphous andrographolide nanosuspensions stabilized by d-α-tocopheryl polyethylene glycol 1000 succinate/sodium lauryl sulfate.

Authors: Hongzhi Qiao; Lihua Chen; Tianqi Rui; Jingxian Wang; Ting Chen; Tingming Fu; Junsong Li; Liuqing Di
Journal: Int J Nanomedicine Date: 2017-02-07

6. Andrographolide ameliorates OVA-induced lung injury in mice by suppressing ROS-mediated NF-κB signaling and NLRP3 inflammasome activation.

Authors: Shuang Peng; Jian Gao; Wen Liu; Chunhong Jiang; Xiaoling Yang; Yang Sun; Wenjie Guo; Qiang Xu
Journal: Oncotarget Date: 2016-12-06

Biological activities and corresponding SARs of andrographolide and its derivatives.

1. Adaptogenic potential of andrographolide: An active principle of the king of bitters (Andrographis paniculata).

2. Andrographolide sulfonate ameliorates lipopolysaccharide-induced acute lung injury in mice by down-regulating MAPK and NF-κB pathways.

3. The antitumor effect of arsenic trioxide on hepatocellular carcinoma is enhanced by andrographolide.

Review 4. Andrographolide, a New Hope in the Prevention and Treatment of Metabolic Syndrome.

5. Fabrication and in vitro/in vivo evaluation of amorphous andrographolide nanosuspensions stabilized by d-α-tocopheryl polyethylene glycol 1000 succinate/sodium lauryl sulfate.

6. Andrographolide ameliorates OVA-induced lung injury in mice by suppressing ROS-mediated NF-κB signaling and NLRP3 inflammasome activation.

7. Synthesis of thioether andrographolide derivatives and their inhibitory effect against cancer cells.

8. Development of a Bifunctional Andrographolide-Based Chemical Probe for Pharmacological Study.

9. Andrographolide relieved pathological pain generated by spared nerve injury model in mice.

10. Andrographolide and Its 14-Aryloxy Analogues Inhibit Zika and Dengue Virus Infection.