Literature DB >> 23436894

The interplay of Graves' disease and twin molar pregnancy.

Jerome Rebollos Barrera1, Mark Anthony Santiago Sandoval, Leslie Quizon Quiwa, Elizabeth Paz-Pacheco.   

Abstract

Twin molar pregnancy with coexistent viable fetus in a patient with Graves' disease is a rare entity. The patient is a 37-year-old woman who was hospitalised owing to persistent vomiting and vaginal bleeding. The pregnancy test was positive and the pelvic ultrasound disclosed twin gestation of complete mole and a coexistent viable 12-week fetus. β-Human chorionic gonadotropin (β-HCG) and free thyroid hormones were both elevated. The patient was also a diagnosed case of Graves' disease prior to this pregnancy. Given the risks for perinatal complications, the patient was offered early termination of pregnancy. She, however, decided to continue her pregnancy and control the hyperthyroidism with an antithyroid drug (ATD). A week after her discharge from the hospital, she had spontaneous abortion and the histopathology of the abortus revealed complete hydatidiform mole and a 13-week fetus.

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Year:  2013        PMID: 23436894      PMCID: PMC3604441          DOI: 10.1136/bcr-2013-008604

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  21 in total

1.  Hydatiform mole with coexisting live fetus in dichorionic twin gestation.

Authors:  N Malhotra; D Deka; D Takkar; S Kochar; S Goel; M C Sharma
Journal:  Eur J Obstet Gynecol Reprod Biol       Date:  2001-02       Impact factor: 2.435

2.  Outcome of twin pregnancies with complete hydatidiform mole and healthy co-twin.

Authors:  Neil J Sebire; Marianne Foskett; Fernando J Paradinas; Rosemary A Fisher; Ros J Francis; Delia Short; Edward S Newlands; Michael J Seckl
Journal:  Lancet       Date:  2002-06-22       Impact factor: 79.321

3.  Prenatal diagnosis of a complete mole coexisting with a dichorionic twin pregnancy: case report.

Authors:  L Bovicelli; T Ghi; G Pilu; A Farina; L Savelli; G Simonazzi; E Calzolari; A Ferlini; D Santini; B Valeri
Journal:  Hum Reprod       Date:  2004-04-07       Impact factor: 6.918

Review 4.  Clinical management and diagnostic possibilities in hydatidiform mole with coexistent fetus.

Authors:  L O Vejerslev
Journal:  Obstet Gynecol Surv       Date:  1991-09       Impact factor: 2.347

5.  Trophoblastic hyperthyroidism: clinical and biochemical features of five cases.

Authors:  R Rajatanavin; L O Chailurkit; S Srisupandit; S Tungtrakul; S Bunyaratvej
Journal:  Am J Med       Date:  1988-08       Impact factor: 4.965

6.  Hydatidiform mole coexistent with a twin live fetus: a national collaborative study in Japan.

Authors:  H Matsui; S Sekiya; T Hando; N Wake; Y Tomoda
Journal:  Hum Reprod       Date:  2000-03       Impact factor: 6.918

7.  The management of choriocarcinoma causing severe thyrotoxicosis. Two case reports.

Authors:  W P Soutter; R Norman; R W Green-Thompson
Journal:  Br J Obstet Gynaecol       Date:  1981-09

Review 8.  Epidemiology of hydatidiform mole and choriocarcinoma.

Authors:  M B Bracken; L A Brinton; K Hayashi
Journal:  Epidemiol Rev       Date:  1984       Impact factor: 6.222

9.  Maternal hyperthyroidism and congenital malformation in the offspring.

Authors:  N Momotani; K Ito; N Hamada; Y Ban; Y Nishikawa; T Mimura
Journal:  Clin Endocrinol (Oxf)       Date:  1984-06       Impact factor: 3.478

Review 10.  Hyperthyroidism in pregnancy.

Authors:  Jorge H Mestman
Journal:  Best Pract Res Clin Endocrinol Metab       Date:  2004-06       Impact factor: 4.690

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