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Literature DB >> 23436779

A self-adjuvanting supramolecular vaccine carrying a folded protein antigen.

Gregory A Hudalla¹, Justin A Modica, Ye F Tian, Jai S Rudra, Anita S Chong, Tao Sun, Milan Mrksich, Joel H Collier.

Abstract

This work illustrates a strategy for the design of molecularly defined immunotherapies, using a blend of supramolecular peptide self-assembly and active site-directed protein capture.

Entities: CellLine Chemical Disease Gene Species

Keywords: biomolecular materials; immunotherapy; nanofibers; proteins; self-assembly

Mesh：

Substances：

Year: 2013 PMID： 23436779 PMCID： PMC3817840 DOI： 10.1002/adhm.201200435

Source DB: PubMed Journal: Adv Healthc Mater ISSN： 2192-2640 Impact factor: 9.933

31 in total

1. Exploiting lymphatic transport and complement activation in nanoparticle vaccines.

Authors: Sai T Reddy; André J van der Vlies; Eleonora Simeoni; Veronique Angeli; Gwendalyn J Randolph; Conlin P O'Neil; Leslie K Lee; Melody A Swartz; Jeffrey A Hubbell
Journal: Nat Biotechnol Date: 2007-09-16 Impact factor: 54.908

2. Cytochrome display on amyloid fibrils.

Authors: Andrew J Baldwin; Reto Bader; John Christodoulou; Cait E MacPhee; Christopher M Dobson; Paul D Barker
Journal: J Am Chem Soc Date: 2006-02-22 Impact factor: 15.419

3. Modular self-assembling biomaterials for directing cellular responses.

Authors: Joel H Collier
Journal: Soft Matter Date: 2008 Impact factor: 3.679

4. Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells.

Authors: F Re; J L Strominger
Journal: J Biol Chem Date: 2001-07-26 Impact factor: 5.157

Review 5. Multi-component extracellular matrices based on peptide self-assembly.

Authors: Joel H Collier; Jai S Rudra; Joshua Z Gasiorowski; Jangwook P Jung
Journal: Chem Soc Rev Date: 2010-07-05 Impact factor: 54.564

6. Multivalent display of proteins on viral nanoparticles using molecular recognition and chemical ligation strategies.

Authors: P Arno Venter; Anouk Dirksen; Diane Thomas; Marianne Manchester; Philip E Dawson; Anette Schneemann
Journal: Biomacromolecules Date: 2011-05-13 Impact factor: 6.988

7. Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices.

Authors: Jangwook P Jung; José V Moyano; Joel H Collier
Journal: Integr Biol (Camb) Date: 2011-01-19 Impact factor: 2.192

8. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.

Authors: A Poltorak; X He; I Smirnova; M Y Liu; C Van Huffel; X Du; D Birdwell; E Alejos; M Silva; C Galanos; M Freudenberg; P Ricciardi-Castagnoli; B Layton; B Beutler
Journal: Science Date: 1998-12-11 Impact factor: 47.728

9. Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses.

Authors: James J Moon; Heikyung Suh; Anna Bershteyn; Matthias T Stephan; Haipeng Liu; Bonnie Huang; Mashaal Sohail; Samantha Luo; Soong Ho Um; Htet Khant; Jessica T Goodwin; Jenelyn Ramos; Wah Chiu; Darrell J Irvine
Journal: Nat Mater Date: 2011-02-20 Impact factor: 43.841

10. Peptide nanoparticles as novel immunogens: design and analysis of a prototypic severe acute respiratory syndrome vaccine.

Authors: Tais A P F Pimentel; Zhe Yan; Scott A Jeffers; Kathryn V Holmes; Robert S Hodges; Peter Burkhard
Journal: Chem Biol Drug Des Date: 2009-01 Impact factor: 2.817

35 in total

Review 1. Supramolecular biomaterials.

Authors: Matthew J Webber; Eric A Appel; E W Meijer; Robert Langer
Journal: Nat Mater Date: 2016-01 Impact factor: 43.841

A self-adjuvanting supramolecular vaccine carrying a folded protein antigen.

1. Exploiting lymphatic transport and complement activation in nanoparticle vaccines.

2. Cytochrome display on amyloid fibrils.

3. Modular self-assembling biomaterials for directing cellular responses.

4. Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells.

Review 5. Multi-component extracellular matrices based on peptide self-assembly.

6. Multivalent display of proteins on viral nanoparticles using molecular recognition and chemical ligation strategies.

7. Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices.

8. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.

9. Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses.

10. Peptide nanoparticles as novel immunogens: design and analysis of a prototypic severe acute respiratory syndrome vaccine.

Review 1. Supramolecular biomaterials.

Review 2. Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials.

3. MyD88 in antigen-presenting cells is not required for CD4+ T-cell responses during peptide nanofiber vaccination.

4. A Supramolecular Vaccine Platform Based on α-Helical Peptide Nanofibers.

Review 5. Supramolecular biofunctional materials.

6. Vaccine Adjuvant Incorporation Strategy Dictates Peptide Amphiphile Micelle Immunostimulatory Capacity.

Review 7. Beyond antigens and adjuvants: formulating future vaccines.

8. Titrating T-cell epitopes within self-assembled vaccines optimizes CD4+ helper T cell and antibody outputs.

9. Self-assembled glycopeptide nanofibers as modulators of galectin-1 bioactivity.

10. Engaging adaptive immunity with biomaterials.