| Literature DB >> 23434429 |
Münci Yağcı1, Zeynep Arzu Yegin, Nalan Akyürek, Handan Kayhan, Zübeyde Nur Ozkurt, Gülsan Türköz Sucak, Rauf Haznedar.
Abstract
This prospective study was planned to determine the intercourse between translationally controlled tumor protein (TCTP)/histamine releasing factor (HRF)/histamine pathway and angiogenesis in chronic lymphocytic leukemia (CLL). A total of 153 CLL patients were included. Serum histamine levels were higher in CLL patients. A positive correlation was found between microvessel density (MVD)-mast cell (MC) count; MVD-TCTP/HRF and MC count-TCTP/HRF. Microvessel density, MC and ZAP 70 were significantly higher in TCTP/HRF-positive group. Time to first treatment was shorter in patients with increased MVD and TCTP/HRF. Further data is essential to ascertain the role of TCTP/HRF pathway in tumor angiogenesis and CLL prognosis.Entities:
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Year: 2013 PMID: 23434429 DOI: 10.1016/j.leukres.2013.01.005
Source DB: PubMed Journal: Leuk Res ISSN: 0145-2126 Impact factor: 3.156