OBJECTIVES: Diabetes is a risk factor for active tuberculosis (TB). Data are limited regarding the association between diabetes and TB drug resistance and treatment outcomes. We examined characteristics of TB patients with and without diabetes in a Peruvian cohort at high risk for drug-resistant TB. Among TB patients with diabetes (TB-DM), we studied the association between diabetes clinical/management characteristics and TB drug resistance and treatment outcomes. METHODS: During 2005-2008, adults with suspected TB with respiratory symptoms in Lima, Peru, who received rapid drug susceptibility testing (DST), were prospectively enrolled and followed during treatment. Bivariate and Kaplan-Meier analyses were used to examine the relationships of diabetes characteristics with drug-resistant TB and TB outcomes. RESULTS: Of 1671 adult TB patients enrolled, 186 (11.1%) had diabetes. TB-DM patients were significantly more likely than TB patients without diabetes to be older, have had no previous TB treatment, and to have a body mass index (BMI) >18.5 kg/m(2) (p<0.05). In patients without and with previous TB treatment, the prevalence of multidrug-resistant TB was 23% and 26%, respectively, among patients without diabetes, and 12% and 28%, respectively, among TB-DM patients. Among 149 TB-DM patients with DST results, 104 (69.8%) had drug-susceptible TB and 45 (30.2%) had drug-resistant TB, of whom 29 had multidrug-resistant TB. There was no association between diabetes characteristics and drug-resistant TB. Of 136 TB-DM patients with outcome information, 107 (78.7%) had a favorable TB outcome; active diabetes management was associated with a favorable outcome. CONCLUSIONS: Diabetes was common in a cohort of TB patients at high risk for drug-resistant TB. Despite prevalent multidrug-resistant TB among TB-DM patients, the majority had a favorable TB treatment outcome.
OBJECTIVES:Diabetes is a risk factor for active tuberculosis (TB). Data are limited regarding the association between diabetes and TB drug resistance and treatment outcomes. We examined characteristics of TB patients with and without diabetes in a Peruvian cohort at high risk for drug-resistant TB. Among TB patients with diabetes (TB-DM), we studied the association between diabetes clinical/management characteristics and TB drug resistance and treatment outcomes. METHODS: During 2005-2008, adults with suspected TB with respiratory symptoms in Lima, Peru, who received rapid drug susceptibility testing (DST), were prospectively enrolled and followed during treatment. Bivariate and Kaplan-Meier analyses were used to examine the relationships of diabetes characteristics with drug-resistant TB and TB outcomes. RESULTS: Of 1671 adult TB patients enrolled, 186 (11.1%) had diabetes. TB-DMpatients were significantly more likely than TB patients without diabetes to be older, have had no previous TB treatment, and to have a body mass index (BMI) >18.5 kg/m(2) (p<0.05). In patients without and with previous TB treatment, the prevalence of multidrug-resistant TB was 23% and 26%, respectively, among patients without diabetes, and 12% and 28%, respectively, among TB-DMpatients. Among 149 TB-DMpatients with DST results, 104 (69.8%) had drug-susceptible TB and 45 (30.2%) had drug-resistant TB, of whom 29 had multidrug-resistant TB. There was no association between diabetes characteristics and drug-resistant TB. Of 136 TB-DMpatients with outcome information, 107 (78.7%) had a favorable TB outcome; active diabetes management was associated with a favorable outcome. CONCLUSIONS:Diabetes was common in a cohort of TB patients at high risk for drug-resistant TB. Despite prevalent multidrug-resistant TB among TB-DMpatients, the majority had a favorable TB treatment outcome.
Authors: C Pérez-Guzman; A Torres-Cruz; H Villarreal-Velarde; M A Salazar-Lezama; M H Vargas Journal: Int J Tuberc Lung Dis Date: 2001-05 Impact factor: 2.373
Authors: Alfredo Ponce-De-Leon; Ma de Lourdes Garcia-Garcia Md; Ma Cecilia Garcia-Sancho; Francisco J Gomez-Perez; Jose Luis Valdespino-Gomez; Gustavo Olaiz-Fernandez; Rosalba Rojas; Leticia Ferreyra-Reyes; Bulmaro Cano-Arellano; Miriam Bobadilla; Peter M Small; Jose Sifuentes-Osornio Journal: Diabetes Care Date: 2004-07 Impact factor: 19.112
Authors: Gustavo E Velásquez; Martin Yagui; J Peter Cegielski; Luis Asencios; Jaime Bayona; Cesar Bonilla; Hector O Jave; Gloria Yale; Carmen Suárez; Sidney Atwood; Carmen C Contreras; Sonya S Shin Journal: Emerg Infect Dis Date: 2011-03 Impact factor: 6.883
Authors: Matthew J Magee; Argita D Salindri; Nang Thu Thu Kyaw; Sara C Auld; J Sonya Haw; Guillermo E Umpierrez Journal: Curr Diab Rep Date: 2018-08-09 Impact factor: 4.810
Authors: R C Koesoemadinata; S M McAllister; N N M Soetedjo; P Santoso; R Ruslami; H Damayanti; N Rahmadika; B Alisjahbana; R van Crevel; P C Hill Journal: Public Health Action Date: 2021-12-21
Authors: Susan Martins Pereira; Gleide Santos de Araújo; Carlos Antônio de Souza Teles Santos; Maeli Gomes de Oliveira; Maurício Lima Barreto Journal: Rev Saude Publica Date: 2016-12-22 Impact factor: 2.106
Authors: Elisa Tagliani; Mohamed Osman Hassan; Yacine Waberi; Maria Rosaria De Filippo; Dennis Falzon; Anna Dean; Matteo Zignol; Philip Supply; Mohamed Ali Abdoulkader; Hawa Hassangue; Daniela Maria Cirillo Journal: Sci Rep Date: 2017-12-15 Impact factor: 4.379