| Literature DB >> 23434031 |
Zacharia S Cheruvallath1, Stephen L Gwaltney, Mark Sabat, Mingnam Tang, Jun Feng, Haixia Wang, Joanne Miura, Prasuna Guntupalli, Andy Jennings, David Hosfield, Bumsup Lee, Yiqin Wu.
Abstract
Guided by co-crystal structures of compounds 15, 22 and 30, an SBDD approach led to the discovery of the 6-methyl pyridone series as a novel class of GKAs that potently activate GK in enzyme and cell assays. Anti-diabetic OGTT efficacy was demonstrated with 54 in a mouse model of type 2 diabetes.Entities:
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Year: 2013 PMID： 23434031 DOI： 10.1016/j.bmcl.2013.01.093
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823