| Literature DB >> 23433789 |
I Puxeddu1, P Italiani, P Giungato, F Pratesi, F Panza, D Bartaloni, V Rocchi, I Del Corso, D Boraschi, P Migliorini.
Abstract
Overproduction of IL-18 has been described in chronic urticaria. To evaluate free IL-18 and IL-33 in chronic spontaneous urticaria (CSU). IL-18, its inhibitor IL-18BP, IL-33 and its soluble receptor ST2 (sST2) were measured (ELISA) in the sera of 73 CSU patients. Free IL-18 was calculated (law of mass action). Autologous serum skin test (ASST) was performed in all patients. Total IL-18, IL-18BP and free IL-18 serum levels were significantly higher in CSU than in controls. IL-18 and IL-18BP increased significantly in both ASST-positive and negative subgroups. Free IL-18 resulted significantly higher in the ASST-negative, but not in the ASST-positive subgroup. No differences in IL-33/sST2 levels were detected between CSU and controls. Increased levels of free IL-18 and IL-18BP, but not IL-33, was detected in CSU. Whether IL-18 up-regulation is a consequence of inflammation or one of the causes of the pathology needs to be addressed.Entities:
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Year: 2013 PMID： 23433789 DOI： 10.1016/j.cyto.2013.01.015
Source DB: PubMed Journal: Cytokine ISSN： 1043-4666 Impact factor: 3.861