BACKGROUND: There are few recent European studies of mortality after intracerebral hemorrhage (ICH), particularly long-term follow-up studies. No previous European studies have included information on leukoaraiosis. METHODS: We studied all consecutive patients hospitalized with a first-ever intracerebral hemorrhage between 2005 and 2009 in a well-defined area and assessed the prognostic value of various baseline clinical and radiologic factors. Leukoaraiosis was scored on the baseline computed tomographic (CT) scan as described by van Swieten et al, with an overall score from 0 to 4. RESULTS: One hundred thirty-four patients were followed up for a median of 4.7 years (interquartile range 2.5-6.6). Overall mortality was 23% at 2 days, 30% at 7 days, 37% at 30 days, 46% at 1 year, and 53% at 2 years. Factors independently associated with increased 30-day mortality were warfarin use, leukoaraiosis score, intraventricular hemorrhage, and Glasgow Coma Scale (GCS) score. Factors independently associated with long-term mortality in the 85 patients who survived the first 30 days were leukoaraiosis score, coronary heart disease, and initial GCS score. Recurrent ICH occurred in 4.5% and was significantly more frequent after lobar ICH than after ICH in other locations (11.1% v 0%; P = .025). CONCLUSIONS: In unselected patients in Southern Norway with first-ever ICH, severe leukoaraiosis is independently associated with both 30-day and long-term mortality in 30-day survivors. Warfarin is independently associated with 30-day mortality and coronary heart disease with long-term mortality in 30-day survivors. Recurrent ICH is more frequent after lobar ICH than after ICH in other locations.
BACKGROUND: There are few recent European studies of mortality after intracerebral hemorrhage (ICH), particularly long-term follow-up studies. No previous European studies have included information on leukoaraiosis. METHODS: We studied all consecutive patients hospitalized with a first-ever intracerebral hemorrhage between 2005 and 2009 in a well-defined area and assessed the prognostic value of various baseline clinical and radiologic factors. Leukoaraiosis was scored on the baseline computed tomographic (CT) scan as described by van Swieten et al, with an overall score from 0 to 4. RESULTS: One hundred thirty-four patients were followed up for a median of 4.7 years (interquartile range 2.5-6.6). Overall mortality was 23% at 2 days, 30% at 7 days, 37% at 30 days, 46% at 1 year, and 53% at 2 years. Factors independently associated with increased 30-day mortality were warfarin use, leukoaraiosis score, intraventricular hemorrhage, and Glasgow Coma Scale (GCS) score. Factors independently associated with long-term mortality in the 85 patients who survived the first 30 days were leukoaraiosis score, coronary heart disease, and initial GCS score. Recurrent ICH occurred in 4.5% and was significantly more frequent after lobar ICH than after ICH in other locations (11.1% v 0%; P = .025). CONCLUSIONS: In unselected patients in Southern Norway with first-ever ICH, severe leukoaraiosis is independently associated with both 30-day and long-term mortality in 30-day survivors. Warfarin is independently associated with 30-day mortality and coronary heart disease with long-term mortality in 30-day survivors. Recurrent ICH is more frequent after lobar ICH than after ICH in other locations.
Authors: Seong Ho Jeong; Sung Soo Ahn; Minyoul Baik; Ki Hoon Kim; JoonSang Yoo; Kyoungsub Kim; Hye Sun Lee; Jimin Ha; Young Dae Kim; Ji Hoe Heo; Hyo Suk Nam Journal: PLoS One Date: 2018-04-27 Impact factor: 3.240
Authors: Mahesh Kate; Laura Gioia; Thomas Jeerakathil; Michael D Hill; Bronwen Gould; Rebecca McCourt; Dar Dowlatshahi; Shelagh Coutts; Jayme Kosior; Andrew Demchuk; Brian Buck; Kenneth Butcher Journal: PLoS One Date: 2019-03-11 Impact factor: 3.240
Authors: Andrés da Silva-Candal; Iria López-Dequidt; Manuel Rodriguez-Yañez; Paulo Ávila-Gómez; José Manuel Pumar; José Castillo; Tomás Sobrino; Francisco Campos; Ramón Iglesias-Rey; Pablo Hervella Journal: Stroke Vasc Neurol Date: 2021-03-23
Authors: G Banerjee; G Ambler; D Wilson; I C Hostettler; C Shakeshaft; S Lunawat; H Cohen; T Yousry; R Al-Shahi Salman; G Y H Lip; H Houlden; K W Muir; M M Brown; H R Jäger; D J Werring Journal: Eur J Neurol Date: 2020-04-28 Impact factor: 6.288