OBJECTIVE: To analyze treatment outcome and the accuracy of positive sputum smear at 2 months to predict treatment failure in a cohort of patients with tuberculosis (TB) in a rural setting in Angola. DESIGN: Observational study of patients with TB from January 2009 to August 2010 in Hospital Nossa Senhora da Paz in Angola. A multivariate analysis was performed to identify variables associated with treatment failure and death. Sensitivity, specificity, positive and negative predictive values and likelihood ratios to define the accuracy of a positive sputum smear at 2 months to predict treatment failure were calculated. RESULTS: One thousand four hundred and twenty-five patients were diagnosed with TB. Overall, 526 patients were cured from TB and 419 had treatment completed, so 945 (66·3%) patients achieved treatment success. The outcomes of the remaining patients were: 91 (6·4%) had treatment failure, 100 (7%) died, 49 (3·4%) interrupted treatment, and 240 (16·8%) were transferred out. Variables associated with a higher risk of treatment failure were previously treated patients (odds ratio, 2·36; 95% confidence interval, 1·32-4·2) and positive sputum smear at 2 months (odds ratio, 9·81; 95% confidence interval, 5·88-16·36). Among the group of 551 patients with sputum smear confirmed at diagnosis and specimens taken at 2 and 5 months, the positive predictive value (31%) and the positive likelihood ratio (3·21) of a positive sputum smear taken at 2 months to predict treatment failure were low. CONCLUSIONS: Patients with positive sputum smear at 2 months have a higher risk of treatment failure. However, this by itself is a poor predictor of treatment failure.
OBJECTIVE: To analyze treatment outcome and the accuracy of positive sputum smear at 2 months to predict treatment failure in a cohort of patients with tuberculosis (TB) in a rural setting in Angola. DESIGN: Observational study of patients with TB from January 2009 to August 2010 in Hospital Nossa Senhora da Paz in Angola. A multivariate analysis was performed to identify variables associated with treatment failure and death. Sensitivity, specificity, positive and negative predictive values and likelihood ratios to define the accuracy of a positive sputum smear at 2 months to predict treatment failure were calculated. RESULTS: One thousand four hundred and twenty-five patients were diagnosed with TB. Overall, 526 patients were cured from TB and 419 had treatment completed, so 945 (66·3%) patients achieved treatment success. The outcomes of the remaining patients were: 91 (6·4%) had treatment failure, 100 (7%) died, 49 (3·4%) interrupted treatment, and 240 (16·8%) were transferred out. Variables associated with a higher risk of treatment failure were previously treated patients (odds ratio, 2·36; 95% confidence interval, 1·32-4·2) and positive sputum smear at 2 months (odds ratio, 9·81; 95% confidence interval, 5·88-16·36). Among the group of 551 patients with sputum smear confirmed at diagnosis and specimens taken at 2 and 5 months, the positive predictive value (31%) and the positive likelihood ratio (3·21) of a positive sputum smear taken at 2 months to predict treatment failure were low. CONCLUSIONS:Patients with positive sputum smear at 2 months have a higher risk of treatment failure. However, this by itself is a poor predictor of treatment failure.
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