BACKGROUND: This study sought to estimate the severity, etiology, and clinical importance of treatment-related lymphopenia in patients with stage III non-small-cell lung cancer. METHODS: Serial lymphocyte counts and survival were analyzed retrospectively in 47 patients accounting for known prognostic factors. RESULTS: Total lymphocyte counts (TLCs) were normal before therapy and did not change following neoadjuvant chemotherapy. Following radiation, TLC fell by 67% (median 500 cells/mm(3), p <.00001). Multivariate analysis revealed an association between severe TLC and survival (HR 1.70, 95% CI: 0.8-3.6). CONCLUSIONS: Rapid and severe lymphopenia occurred in 50% of patients following radiation which was associated with reduced survival.
BACKGROUND: This study sought to estimate the severity, etiology, and clinical importance of treatment-related lymphopenia in patients with stage III non-small-cell lung cancer. METHODS: Serial lymphocyte counts and survival were analyzed retrospectively in 47 patients accounting for known prognostic factors. RESULTS: Total lymphocyte counts (TLCs) were normal before therapy and did not change following neoadjuvant chemotherapy. Following radiation, TLC fell by 67% (median 500 cells/mm(3), p <.00001). Multivariate analysis revealed an association between severe TLC and survival (HR 1.70, 95% CI: 0.8-3.6). CONCLUSIONS: Rapid and severe lymphopenia occurred in 50% of patients following radiation which was associated with reduced survival.
Authors: Stuart A Grossman; Xiaobu Ye; Glenn Lesser; Andrew Sloan; Hetty Carraway; Serena Desideri; Steven Piantadosi Journal: Clin Cancer Res Date: 2011-07-07 Impact factor: 12.531
Authors: Hauke Winter; Natasja K van den Engel; Margareta Rusan; Nina Schupp; Christian H Poehlein; Hong-Ming Hu; Rudolf A Hatz; Walter J Urba; Karl-Walter Jauch; Bernard A Fox; Dominik Rüttinger Journal: J Thorac Dis Date: 2011-06 Impact factor: 2.895
Authors: Anna M Dahlin; Maria L Henriksson; Bethany Van Guelpen; Roger Stenling; Ake Oberg; Jörgen Rutegård; Richard Palmqvist Journal: Mod Pathol Date: 2011-01-14 Impact factor: 7.842
Authors: P Lissoni; F Brivio; L Fumagalli; G Messina; V Ghezzi; L Frontini; L Giani; M Vaghi; A Ardizzoia; G S Gardani Journal: Int J Biol Markers Date: 2004 Apr-Jun Impact factor: 2.659
Authors: M A Socinski; C Zhang; J E Herndon; R O Dillman; G Clamon; E Vokes; W Akerley; J Crawford; M C Perry; S L Seagren; M R Green Journal: Ann Oncol Date: 2004-07 Impact factor: 32.976
Authors: Susannah Yovino; Lawrence Kleinberg; Stuart A Grossman; Manisha Narayanan; Eric Ford Journal: Cancer Invest Date: 2013-02 Impact factor: 2.176
Authors: Isabelle Ray-Coquard; Claire Cropet; Martine Van Glabbeke; Catherine Sebban; Axel Le Cesne; Ian Judson; Olivier Tredan; Jaap Verweij; Pierre Biron; Inthidar Labidi; Jean-Paul Guastalla; Thomas Bachelot; David Perol; Sylvie Chabaud; Pancras C W Hogendoorn; Philippe Cassier; Armelle Dufresne; Jean-Yves Blay Journal: Cancer Res Date: 2009-06-23 Impact factor: 12.701
Authors: Jian L Campian; Anna F Piotrowski; Xiaobu Ye; Frances T Hakim; Jeremy Rose; Xiao-Yi Yan; Yao Lu; Ronald Gress; Stuart A Grossman Journal: J Neurooncol Date: 2017-07-29 Impact factor: 4.130
Authors: Grace Lee; Daniel W Kim; Vinayak Muralidhar; Devarati Mitra; Nora K Horick; Christine E Eyler; Theodore S Hong; Lorraine C Drapek; Jill N Allen; Lawrence S Blaszkowsky; Bruce Giantonio; Aparna R Parikh; David P Ryan; Jeffrey W Clark; Jennifer Y Wo Journal: Oncologist Date: 2020-09-12
Authors: Katrin Rabold; Paul R Gielen; Esther D Kers-Rebel; Mihai G Netea; Jan W A Smit; Gosse J Adema; Romana T Netea-Maier Journal: Oncologist Date: 2019-01-03
Authors: Ryoko Suzuki; Steven H Lin; Xiong Wei; Pamela K Allen; James W Welsh; Lauren A Byers; Ritsuko Komaki Journal: Radiother Oncol Date: 2018-02-02 Impact factor: 6.280
Authors: Anna F Piotrowski; Thomas R Nirschl; Esteban Velarde; Lee Blosser; Sudipto Ganguly; Kathleen H Burns; Leo Luznik; John Wong; Charles G Drake; Stuart A Grossman Journal: Oncoimmunology Date: 2018-05-09 Impact factor: 8.110
Authors: Emily S Wu; Titilope Oduyebo; Lauren P Cobb; Diana Cholakian; Xiangrong Kong; Amanda N Fader; Kimberly L Levinson; Edward J Tanner; Rebecca L Stone; Anna Piotrowski; Stuart Grossman; Kara Long Roche Journal: Gynecol Oncol Date: 2015-11-11 Impact factor: 5.482
Authors: Radhe Mohan; Amy Y Liu; Paul D Brown; Anita Mahajan; Jeffrey Dinh; Caroline Chung; Sarah McAvoy; Mary Frances McAleer; Steven H Lin; Jing Li; Amol J Ghia; Cong Zhu; Erik P Sulman; John F de Groot; Amy B Heimberger; Susan L McGovern; Clemens Grassberger; Helen Shih; Susannah Ellsworth; David R Grosshans Journal: Neuro Oncol Date: 2021-02-25 Impact factor: 12.300