BACKGROUND: The impact of moderate alcohol consumption on long-term outcomes of chronic hepatitis C (CH-C) infected patients remains controversial. AIM: To assess the impact of moderate alcohol consumption on long-term outcomes of CH-C patients using population-based data. METHODS: Data were obtained from the Third National Health and Nutrition Examination Survey (NHANES III)-mortality linked files. Alcohol consumption was estimated as grams/day. Multivariate Cox proportional hazards model was utilized to assess the effects of CH-C and alcohol consumption on mortality (all causes, cardiovascular disease, and liver disease). RESULTS: A total of 8985 participants were included as the study cohort. Of these, 218 had CH-C. The follow-up time was 162.95 months for CH-C and 178.27 months for controls. CH-C patients had increased risk for both overall mortality and liver-related mortality. CH-C patients with excessive alcohol consumption had even higher risks for overall mortality and liver-related mortality. The risk of overall mortality associated with CH-C increased with moderate alcohol consumption of 1-19 g/day and heavy alcohol consumption ≥30 g/day. CONCLUSION: Although chronic hepatitis C is associated with increased risks for overall and liver-related mortality, these risks are even higher for patients consuming moderate and excessive amounts of alcohol.
BACKGROUND: The impact of moderate alcohol consumption on long-term outcomes of chronic hepatitis C (CH-C) infectedpatients remains controversial. AIM: To assess the impact of moderate alcohol consumption on long-term outcomes of CH-Cpatients using population-based data. METHODS: Data were obtained from the Third National Health and Nutrition Examination Survey (NHANES III)-mortality linked files. Alcohol consumption was estimated as grams/day. Multivariate Cox proportional hazards model was utilized to assess the effects of CH-C and alcohol consumption on mortality (all causes, cardiovascular disease, and liver disease). RESULTS: A total of 8985 participants were included as the study cohort. Of these, 218 had CH-C. The follow-up time was 162.95 months for CH-C and 178.27 months for controls. CH-Cpatients had increased risk for both overall mortality and liver-related mortality. CH-Cpatients with excessive alcohol consumption had even higher risks for overall mortality and liver-related mortality. The risk of overall mortality associated with CH-C increased with moderate alcohol consumption of 1-19 g/day and heavy alcohol consumption ≥30 g/day. CONCLUSION: Although chronic hepatitis C is associated with increased risks for overall and liver-related mortality, these risks are even higher for patients consuming moderate and excessive amounts of alcohol.
Authors: Anam Khan; Aylin Tansel; Donna L White; Waleed Tallat Kayani; Shah Bano; Jan Lindsay; Hashem B El-Serag; Fasiha Kanwal Journal: Clin Gastroenterol Hepatol Date: 2015-08-06 Impact factor: 11.382
Authors: Anil Suryaprasad; Kathy K Byrd; John T Redd; David G Perdue; M Michele Manos; Brian J McMahon Journal: Am J Public Health Date: 2014-04-22 Impact factor: 9.308
Authors: Bryce D Smith; Geoff A Beckett; Anthony Yartel; Deborah Holtzman; Nita Patel; John W Ward Journal: Am J Public Health Date: 2014-01-16 Impact factor: 9.308
Authors: Wambui G Gathirua-Mwangi; Patrick O Monahan; Mwangi J Murage; Jianjun Zhang Journal: Cancer Causes Control Date: 2017-01-17 Impact factor: 2.506
Authors: Rae Jean Proeschold-Bell; Donna M Evon; Jia Yao; Donna Niedzwiecki; Christina Makarushka; Kelly A Keefe; Ashwin A Patkar; Paolo Mannelli; James C Garbutt; John B Wong; Julius M Wilder; Santanu K Datta; Terra Hodge; Susanna Naggie; Michael W Fried; Andrew J Muir Journal: Hepatology Date: 2020-03-24 Impact factor: 17.425
Authors: Bryce D Smith; Anthony K Yartel; Katherine Krauskopf; Omar I Massoud; Kimberly A Brown; Michael B Fallon; David B Rein Journal: Clin Infect Dis Date: 2015-01-16 Impact factor: 9.079