BACKGROUND AND AIM: Biliary anastomosis is the Achilles' heel of liver transplant. The reported incidence of biliary complications is 5-15% after deceased donor liver transplantation, and 20-34% after right-lobe live donor liver transplantation (LDLT). We report our experience from an LDLT program. METHODS: Between September 2006 and August 2010, 338 liver transplants were performed. Biliary reconstructions were done with an end-to-end choledochocholedochostomy in 307 cases. All recipients were monitored for any evidence of bile leak or stricture. RESULTS: Of 338 transplants performed during this time period, 65 patients had biliary complications (19%). Of these, 30 were biliary leaks, and 35 patients had biliary stricture. Four were cut surface leaks, which settled without any intervention. One patient had leak from primary hepaticojejunostomy, which settled on conservative management. Twenty-five patients had anastomotic leaks, of which 17 underwent endoscopic retrograde cholangiopancreatography and stenting; another eight underwent re-exploration and hepaticojejunostomy. Forty-five patients had biliary strictures. Of these, 10 patients had bile leak initially, followed by biliary stricture. Patients with a double duct anastomosis had a significantly higher risk of developing biliary complications compared with those with a single duct anastomosis. There was no statistically significant difference in survival between those with or without biliary complications. CONCLUSIONS: Biliary complications are common after LDLT. Most leaks will subsequently form strictures. Endoscopic retrograde cholangiopancreatography is the first-line treatment for biliary complications, with surgery required in a minority of cases. The incidence of biliary complications is higher in multiple duct anastomoses. Biliary complications are not associated with increased mortality.
BACKGROUND AND AIM: Biliary anastomosis is the Achilles' heel of liver transplant. The reported incidence of biliary complications is 5-15% after deceased donor liver transplantation, and 20-34% after right-lobe live donor liver transplantation (LDLT). We report our experience from an LDLT program. METHODS: Between September 2006 and August 2010, 338 liver transplants were performed. Biliary reconstructions were done with an end-to-end choledochocholedochostomy in 307 cases. All recipients were monitored for any evidence of bile leak or stricture. RESULTS: Of 338 transplants performed during this time period, 65 patients had biliary complications (19%). Of these, 30 were biliary leaks, and 35 patients had biliary stricture. Four were cut surface leaks, which settled without any intervention. One patient had leak from primary hepaticojejunostomy, which settled on conservative management. Twenty-five patients had anastomotic leaks, of which 17 underwent endoscopic retrograde cholangiopancreatography and stenting; another eight underwent re-exploration and hepaticojejunostomy. Forty-five patients had biliary strictures. Of these, 10 patients had bile leak initially, followed by biliary stricture. Patients with a double duct anastomosis had a significantly higher risk of developing biliary complications compared with those with a single duct anastomosis. There was no statistically significant difference in survival between those with or without biliary complications. CONCLUSIONS: Biliary complications are common after LDLT. Most leaks will subsequently form strictures. Endoscopic retrograde cholangiopancreatography is the first-line treatment for biliary complications, with surgery required in a minority of cases. The incidence of biliary complications is higher in multiple duct anastomoses. Biliary complications are not associated with increased mortality.
Authors: Mehmet Ali Erdoğan; Yasir Furkan Çağın; Yahya Atayan; Yılmaz Bilgiç; Oğuzhan Yıldırım; Ali Riza Çalışkan; Murat Aladağ; Melih Karıncaoğlu; Sezai Yılmaz; Muhsin Murat Harputluoğlu Journal: Turk J Gastroenterol Date: 2020-09 Impact factor: 1.852
Authors: M Harputluoglu; U Demirel; A R Caliskan; A Selimoglu; Y Bilgic; M Aladag; M A Erdogan; R Dertli; Y Atayan; S Yilmaz Journal: Langenbecks Arch Surg Date: 2019-07-20 Impact factor: 3.445
Authors: Samir Abu-Gazala; Kim M Olthoff; David S Goldberg; Abraham Shaked; Peter L Abt Journal: J Gastrointest Surg Date: 2015-12-16 Impact factor: 3.452
Authors: Dayse Pereira da Silva Aparício; José Pinhata Otoch; Edna Frasson de Souza Montero; Muhammad Ali Khan; Everson Luiz de Almeida Artifon Journal: United European Gastroenterol J Date: 2016-11-22 Impact factor: 4.623