Literature DB >> 23432315

Synthesis of 1H-1,2,3-triazoles and study of their antifungal and cytotoxicity activities.

Iara F da Silva1, Prisicila R C Martins, Emanuelly G da Silva, Sabrina B Ferreira, Vitor F Ferreira, Karen Regina C da Costa, Marne C de Vasconcellos, Emerson S Lima, Fernando de C da Silva.   

Abstract

We report herein the results of antifungal activity of fifteen 1,2,3-triazoles against Candida albicans, Candida krusei, Candida parapsilosis, Candida kefyr, Candida tropicalis, Candida dubliniensis, Tricophyton rubrum, Microporum canis and Aspergillus niger. All of the 1,2,3-triazoles were prepared from 1,3-dipolar cyclizations between aryl azides and alkynes catalyzed by Cu(I), and several of the compounds exhibited antifungal activity with low cytotoxicity. The results demonstrated the potential and importance of developing new 1,2,3-triazoles compounds with antifungal activity.

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Year:  2013        PMID： 23432315     DOI： 10.2174/1573406411309080010

Source DB:  PubMed          Journal:  Med Chem        ISSN： 1573-4064            Impact factor:   2.745


  4 in total

1.  Inhibition of phosphotidylinositol-3 kinase pathway by a novel naphthol derivative of betulinic acid induces cell cycle arrest and apoptosis in cancer cells of different origin.

Authors:  R Majeed; A Hamid; P L Sangwan; P K Chinthakindi; S Koul; S Rayees; G Singh; D M Mondhe; M J Mintoo; S K Singh; S K Rath; A K Saxena
Journal:  Cell Death Dis       Date:  2014-10-09       Impact factor: 8.469

2.  Synthesis, antibacterial activity and molecular docking study of vanillin derived 1,4-disubstituted 1,2,3-triazoles as inhibitors of bacterial DNA synthesis.

Authors:  Mumtaz Hussain; Tahir Qadri; Zahid Hussain; Aamer Saeed; Pervaiz Ali Channar; Syeda Aaliya Shehzadi; Mubashir Hassan; Fayaz Ali Larik; Tarique Mahmood; Arif Malik
Journal:  Heliyon       Date:  2019-11-19

3.  Synthesis of Novel Glycerol-Derived 1,2,3-Triazoles and Evaluation of Their Fungicide, Phytotoxic and Cytotoxic Activities.

Authors:  Adilson Vidal Costa; Marcos Vinicius Lacerda de Oliveira; Roberta Tristão Pinto; Luiza Carvalheira Moreira; Ediellen Mayara Corrêa Gomes; Thammyres de Assis Alves; Patrícia Fontes Pinheiro; Vagner Tebaldi de Queiroz; Larissa Fonseca Andrade Vieira; Robson Ricardo Teixeira; Waldir Cintra de Jesus Júnior
Journal:  Molecules       Date:  2017-10-07       Impact factor: 4.411

4.  Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives.

Authors:  Ana T P C Gomes; Rosa Fernandes; Carlos F Ribeiro; João P C Tomé; Maria G P M S Neves; Fernando de C da Silva; Vítor F Ferreira; José A S Cavaleiro
Journal:  Molecules       Date:  2020-03-31       Impact factor: 4.411
  4 in total

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