Mustafa Kurt1, Ibrahim Halil Tanboga2, Eyup Buyukkaya3, Mehmet Fatih Karakas3, Adnan Burak Akçay3, Nihat Sen3. 1. Department of Cardiology, Mustafa Kemal University Medical School, Hatay, Turkey drmustafakurt@yahoo.com. 2. Department of Cardiology, Atatürk University Medical School, Erzurum, Turkey. 3. Department of Cardiology, Mustafa Kemal University Medical School, Hatay, Turkey.
Abstract
BACKGROUND: Red cell distribution width (RDW) has been shown to be helpful in predicting adverse long-term events in patients with cardiovascular diseases. However, to date, no study has been conducted on the relationship between RDW and thromboembolism risk in atrial fibrillation (AF). Therefore, we aimed to investigate the relationship between RDW and CHA2DS2-VASc score used for the evaluation of thromboembolism risk in patients with AF. METHODS: The study population consisted of 320 patients with AF. We calculated CHA2DS2-VASc risk score for each patient and baseline hemoglobin, white blood cell, RDW, mean platelet volume, platelet counts, estimated glomerular filtration rate (eGFR), left ventricular ejection fraction (LVEF), and left atrial volume index (LAVi) were measured. RESULTS: High CHA2DS2-VASc score group had higher RDW, lower LVEF, higher LAVi, and lower eGFR values when compared to the low CHA2DS2-VASc score group. The multivariate logistic regression analysis performed to predict high CHA2DS2-VASc scores revealed that RDW eGFR, LVEF, and LAVi were independent predictors. The area under the receiver-operating characteristic curve of RDW was 0.65 (0.59-0.71, P < .001) to predict high CHA2DS2-VASc score. CONCLUSION: Our study results indicate that RDW values are significantly correlated with CHA2DS2-VASc score in nonanemic patients with AF, while also being independent predictor of high CHA2DS2-VASc score.
BACKGROUND: Red cell distribution width (RDW) has been shown to be helpful in predicting adverse long-term events in patients with cardiovascular diseases. However, to date, no study has been conducted on the relationship between RDW and thromboembolism risk in atrial fibrillation (AF). Therefore, we aimed to investigate the relationship between RDW and CHA2DS2-VASc score used for the evaluation of thromboembolism risk in patients with AF. METHODS: The study population consisted of 320 patients with AF. We calculated CHA2DS2-VASc risk score for each patient and baseline hemoglobin, white blood cell, RDW, mean platelet volume, platelet counts, estimated glomerular filtration rate (eGFR), left ventricular ejection fraction (LVEF), and left atrial volume index (LAVi) were measured. RESULTS: High CHA2DS2-VASc score group had higher RDW, lower LVEF, higher LAVi, and lower eGFR values when compared to the low CHA2DS2-VASc score group. The multivariate logistic regression analysis performed to predict high CHA2DS2-VASc scores revealed that RDW eGFR, LVEF, and LAVi were independent predictors. The area under the receiver-operating characteristic curve of RDW was 0.65 (0.59-0.71, P < .001) to predict high CHA2DS2-VASc score. CONCLUSION: Our study results indicate that RDW values are significantly correlated with CHA2DS2-VASc score in nonanemic patients with AF, while also being independent predictor of high CHA2DS2-VASc score.
Authors: Simone De Jong; Marjolein Neeleman; Jurjen J Luykx; Maarten J ten Berg; Eric Strengman; Hanneke H Den Breeijen; Leon C Stijvers; Jacobine E Buizer-Voskamp; Steven C Bakker; René S Kahn; Steve Horvath; Wouter W Van Solinge; Roel A Ophoff Journal: Hum Mol Genet Date: 2014-01-07 Impact factor: 6.150
Authors: Andrés Ricardo Pérez-Riera; Luiz Carlos de Abreu; Raimundo Barbosa-Barros; José Grindler; Acácio Fernandes-Cardoso; Adrian Baranchuk Journal: Indian Pacing Electrophysiol J Date: 2016-10-20