Literature DB >> 23430576

Interactions of the IGF System with Diabetes and its Vascular Complications.

R P Narayanan1, K W Siddals, A H Heald, J M Gibson.   

Abstract

The insulin-like growth factor (IGF) system is an evolutionarily conserved group of important proteins that are fundamental to life. Indeed, insulin can be viewed as simply a specialized arm of the IGF system that has evolved to regulate primarily metabolic functions. The main purpose of the IGF system is to form a highly refined mechanism for the control of cellular growth, metabolism and survival. Dysregulation of such a system can have serious consequences. In this review we have focussed on the IGF system and its relation to diabetes and the development of cardiometabolic disorders. © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York.

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Year:  2013        PMID： 23430576     DOI： 10.1055/s-0032-1333233

Source DB:  PubMed          Journal:  Exp Clin Endocrinol Diabetes        ISSN： 0947-7349            Impact factor:   2.949


  3 in total

1.  daf-16/FOXO and glod-4/glyoxalase-1 are required for the life-prolonging effect of human insulin under high glucose conditions in Caenorhabditis elegans.

Authors:  Michael Mendler; Andreas Schlotterer; Youssef Ibrahim; Georgi Kukudov; Thomas Fleming; Angelika Bierhaus; Christin Riedinger; Vedat Schwenger; Stephan Herzig; Markus Hecker; Jens Tyedmers; Peter P Nawroth; Michael Morcos
Journal:  Diabetologia       Date:  2014-10-17       Impact factor: 10.122

2.  Circulating IGF-axis protein levels and their relation with levels of plasma adipocytokines and macronutrient consumption in women.

Authors:  Jeannette M Beasley; Nicole M Wedick; Swapnil N Rajpathak; Xiaonan Xue; Michelle D Holmes; Marc J Gunter; Judith Wylie-Rosett; Thomas E Rohan; Michael Pollak; Robert C Kaplan; Frank B Hu; Qi Sun; Howard D Strickler
Journal:  Growth Horm IGF Res       Date:  2014-05-17       Impact factor: 2.372

Review 3.  The Insulin-Like Growth Factor System in Obesity, Insulin Resistance and Type 2 Diabetes Mellitus.

Authors:  Moira S Lewitt; Mairi S Dent; Kerstin Hall
Journal:  J Clin Med       Date:  2014-12-22       Impact factor: 4.241
  3 in total

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