INTRODUCTION: Weight loss interventions have been studied extensively, but methodological limitations negatively affecting applicability in everyday clinical practice are a very common problem in these studies. Despite the fact that obesity is treated mostly in a primary care setting, studies that investigate weight loss interventions in a primary care setting are scarce. Our objective was to assess the effectiveness of a tailor-made weight loss intervention in achieving a clinically significant weight loss in overweight (BMI ≥ 27 kg/m²) women aged 50-60 years in a primary care setting. METHODS: As part of a randomized controlled trial on the effects of a tailor-made weight loss intervention and oral glucosamine sulphate on the incidence of osteoarthritis of the knee in 407 overweight women aged 50-60 years, we analysed the effectiveness of the weight loss intervention in achieving clinically relevant weight loss. RESULTS: At baseline, the mean body weight for all participants was 88.7 ± 13.2 kg, and the mean BMI was 32.4 ± 4.3 kg/m². The percentage of participants that lost ≥5 kg or 5 % of their baseline body weight was 14.8 versus 6.3 % (p = 0.012) at 6 months for the intervention group and the control group, respectively. At 12 months, this was 18.7 versus 14.9 % (p = 0.027). Mean weight gain at 6 months was -0.9 versus 0.9 kg (p < 0.001) for the intervention group and the control group, respectively. At 12 months, this was -0.6 versus 0.6 kg (p = 0.01). At 30 months of follow-up, no significant differences were found between both groups. CONCLUSIONS: This weight loss intervention, which, at short notice, is easily applicable in everyday clinical practice, is effective in achieving clinically significant weight loss in overweight women aged 50-60 over a 12-month period. Long-term weight loss maintenance, however, occurred only marginally. Magnitude of the effect is comparable to that achieved in many other more intensive weight loss interventions.
RCT Entities:
INTRODUCTION:Weight loss interventions have been studied extensively, but methodological limitations negatively affecting applicability in everyday clinical practice are a very common problem in these studies. Despite the fact that obesity is treated mostly in a primary care setting, studies that investigate weight loss interventions in a primary care setting are scarce. Our objective was to assess the effectiveness of a tailor-made weight loss intervention in achieving a clinically significant weight loss in overweight (BMI ≥ 27 kg/m²) women aged 50-60 years in a primary care setting. METHODS: As part of a randomized controlled trial on the effects of a tailor-made weight loss intervention and oral glucosamine sulphate on the incidence of osteoarthritis of the knee in 407 overweight women aged 50-60 years, we analysed the effectiveness of the weight loss intervention in achieving clinically relevant weight loss. RESULTS: At baseline, the mean body weight for all participants was 88.7 ± 13.2 kg, and the mean BMI was 32.4 ± 4.3 kg/m². The percentage of participants that lost ≥5 kg or 5 % of their baseline body weight was 14.8 versus 6.3 % (p = 0.012) at 6 months for the intervention group and the control group, respectively. At 12 months, this was 18.7 versus 14.9 % (p = 0.027). Mean weight gain at 6 months was -0.9 versus 0.9 kg (p < 0.001) for the intervention group and the control group, respectively. At 12 months, this was -0.6 versus 0.6 kg (p = 0.01). At 30 months of follow-up, no significant differences were found between both groups. CONCLUSIONS: This weight loss intervention, which, at short notice, is easily applicable in everyday clinical practice, is effective in achieving clinically significant weight loss in overweight women aged 50-60 over a 12-month period. Long-term weight loss maintenance, however, occurred only marginally. Magnitude of the effect is comparable to that achieved in many other more intensive weight loss interventions.
Authors: Thomas A Wadden; Sheri Volger; David B Sarwer; Marion L Vetter; Adam G Tsai; Robert I Berkowitz; Shiriki Kumanyika; Kathryn H Schmitz; Lisa K Diewald; Ronald Barg; Jesse Chittams; Reneé H Moore Journal: N Engl J Med Date: 2011-11-14 Impact factor: 91.245
Authors: Marion J Franz; Jeffrey J VanWormer; A Lauren Crain; Jackie L Boucher; Trina Histon; William Caplan; Jill D Bowman; Nicolas P Pronk Journal: J Am Diet Assoc Date: 2007-10
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Authors: Jyrki Taurio; Jorma Järvinen; Elina J Hautaniemi; Arttu Eräranta; Jani Viitala; Klaus Nordhausen; Katri Kaukinen; Jukka Mustonen; Ilkka H Pörsti Journal: Prev Med Rep Date: 2020-05-13