Literature DB >> 23429643

New drugs for methicillin-resistant Staphylococcus aureus: an update.

Krishan Kumar1, Sidharth Chopra.   

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) remains a leading cause of bacterial infections worldwide, with a dwindling repertoire of effective antimicrobials active against it. This review aims to provide an update on novel anti-MRSA molecules currently under pre-clinical and clinical development, with emphasis on their mechanism of action. This review is limited to molecules that target the pathogen directly and does not detail immunomodulatory anti-infectives.

Entities:  

Keywords:  MRSA; antibiotics; mechanism of action

Mesh：

Substances：

Year:  2013        PMID： 23429643     DOI： 10.1093/jac/dkt045

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  15 in total

1.  AN483, a new anti-MRSA compound from Streptomyces sp.

Authors:  Yun J Kwon; Mi-Jin Sohn; Hiroyuki Koshino; Chang-Jin Kim; Won-Gon Kim
Journal:  J Antibiot (Tokyo)       Date:  2016-01-13       Impact factor: 2.649

2.  Erythrocyte membrane-coated nanogel for combinatorial antivirulence and responsive antimicrobial delivery against Staphylococcus aureus infection.

Authors:  Yue Zhang; Jianhua Zhang; Wansong Chen; Pavimol Angsantikul; Kevin A Spiekermann; Ronnie H Fang; Weiwei Gao; Liangfang Zhang
Journal:  J Control Release       Date:  2017-01-10       Impact factor: 9.776

3.  Companies Take Aim at MRSA Infections.

Authors:  Chris Fellner
Journal:  P T       Date:  2016-02

Review 4.  Advances in MRSA drug discovery: where are we and where do we need to be?

Authors:  Michio Kurosu; Shajila Siricilla; Katsuhiko Mitachi
Journal:  Expert Opin Drug Discov       Date:  2013-07-06       Impact factor: 6.098

5.  Vancomycin Use in a Paediatric Intensive Care Unit of a Tertiary Care Hospital.

Authors:  Kannan Sridharan; Amal Al-Daylami; Reema Ajjawi; Husain Am Al Ajooz
Journal:  Paediatr Drugs       Date:  2019-08       Impact factor: 3.022

6.  AFN-1252 is a potent inhibitor of enoyl-ACP reductase from Burkholderia pseudomallei--Crystal structure, mode of action, and biological activity.

Authors:  Krishnamurthy Narasimha Rao; Anirudha Lakshminarasimhan; Sarah Joseph; Swathi U Lekshmi; Ming-Seong Lau; Mohammed Takhi; Kandepu Sreenivas; Sheila Nathan; Rohana Yusof; Noorsaadah Abd Rahman; Murali Ramachandra; Thomas Antony; Hosahalli Subramanya
Journal:  Protein Sci       Date:  2015-04-02       Impact factor: 6.725

Review 7.  Antimicrobial peptides and peptidomimetics - potent therapeutic allies for staphylococcal infections.

Authors:  Haroon Mohammad; Shankar Thangamani; Mohamed N Seleem
Journal:  Curr Pharm Des       Date:  2015       Impact factor: 3.116

8.  Phytochemical prospection and modulation of antibiotic activity in vitro by Lippia origanoides H.B.K. in methicillin resistant Staphylococcus aureus.

Authors:  Humberto Medeiros Barreto; Filipe Cerqueira Fontinele; Aldeídia Pereira de Oliveira; Daniel Dias Rufino Arcanjo; Bernadete Helena Cavalcanti Dos Santos; Aislan Pereira Lira de Abreu; Henrique Douglas Melo Coutinho; Romezio Alves Carvalho da Silva; Taciana Oliveira de Sousa; Maria das Graças Freire de Medeiros; Antonia Maria das Graças Lopes Citó; José Arimateia Dantas Lopes
Journal:  Biomed Res Int       Date:  2014-02-10       Impact factor: 3.411

9.  Branched Peptide, B2088, Disrupts the Supramolecular Organization of Lipopolysaccharides and Sensitizes the Gram-negative Bacteria.

Authors:  Rajamani Lakshminarayanan; Wei Xiang Tan; Thet Tun Aung; Eunice Tze Leng Goh; Nandhakumar Muruganantham; Jianguo Li; Jamie Ya Ting Chang; Neha Dikshit; Padmanabhan Saraswathi; Rayne Rui Lim; Tse Siang Kang; Vanniarajan Balamuralidhar; Bindu Sukumaran; Chandra S Verma; Jayaraman Sivaraman; Shyam Sunder Chaurasia; Shouping Liu; Roger W Beuerman
Journal:  Sci Rep       Date:  2016-05-13       Impact factor: 4.379

10.  Phytocompounds and modulatory effects of Anacardium microcarpum (cajui) on antibiotic drugs used in clinical infections.

Authors:  Valter M Barbosa-Filho; Emily P Waczuk; Nadghia F Leite; Irwin R A Menezes; José G M da Costa; Sírleis R Lacerda; Isaac A Adedara; Henrique Douglas Melo Coutinho; Thais Posser; Jean P Kamdem
Journal:  Drug Des Devel Ther       Date:  2015-11-06       Impact factor: 4.162
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