PURPOSE OF REVIEW: To discuss the current combination treatments that involve existing as well as novel drugs that show promise for the treatment of neovascular age-related macular degeneration. RECENT FINDINGS: Photodynamic therapy in combination with antivascular endothelial growth factor (VEGF) and steroids is currently used as a second-line therapy in patients not responding to monotherapy with anti-VEGF agents or in whom the treatment burden of monthly injections is too great. It is used as a primary therapy for idiopathic polypoidal choroidal vasculopathy. Radiation and antiplatelet-derived growth factor therapy show promising results and are currently under investigation. SUMMARY: Using combination treatments that target other pathways involved in angiogenesis will hopefully improve on the results of current anti-VEGF agents and may result in greater visual improvement and more convenient dosing regimens.
PURPOSE OF REVIEW: To discuss the current combination treatments that involve existing as well as novel drugs that show promise for the treatment of neovascular age-related macular degeneration. RECENT FINDINGS: Photodynamic therapy in combination with antivascular endothelial growth factor (VEGF) and steroids is currently used as a second-line therapy in patients not responding to monotherapy with anti-VEGF agents or in whom the treatment burden of monthly injections is too great. It is used as a primary therapy for idiopathic polypoidal choroidal vasculopathy. Radiation and antiplatelet-derived growth factor therapy show promising results and are currently under investigation. SUMMARY: Using combination treatments that target other pathways involved in angiogenesis will hopefully improve on the results of current anti-VEGF agents and may result in greater visual improvement and more convenient dosing regimens.
Authors: Maziar Mohammadi; Kisha Patel; Seyedeh P Alaie; Ron B Shmueli; Cagri G Besirli; Ronald G Larson; Jordan J Green Journal: Acta Biomater Date: 2018-04-21 Impact factor: 8.947
Authors: Aniruddha Agarwal; William R Rhoades; Mostafa Hanout; Mohamed Kamel Soliman; Salman Sarwar; Mohammad Ali Sadiq; Yasir Jamal Sepah; Diana V Do; Quan Dong Nguyen Journal: Clin Ophthalmol Date: 2015-06-05
Authors: Francesco Parmeggiani; Carla Enrica Gallenga; Ciro Costagliola; Francesco Semeraro; Mario R Romano; Roberto Dell'Omo; Andrea Russo; Katia De Nadai; Donato Gemmati; Sergio D'Angelo; Elena Bolletta; Francesco Saverio Sorrentino Journal: Sci Rep Date: 2019-02-22 Impact factor: 4.379