BACKGROUND/AIMS: We hypothesized that sepsis could have an impact on the sensitivity of serum and urinary neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (CysC) for acute kidney injury (AKI) diagnosis in critically ill children. METHODS: Serum NGAL (sNGAL) and urinary NGAL (uNGAL) and CysC were measured daily in the first 48 h from pediatric intensive care unit admission in 11 consecutive critically ill children with severe sepsis; a single measurement was made in a population of 10 healthy controls undergoing minor ambulatory surgery to exclude possible biases in the laboratory methods. RESULTS: uNGAL, serum CysC (sCysC), and urinary CysC (uCysC) levels were significantly increased in patients with septic AKI compared with septic patients without AKI, while sNGAL levels were not significantly different between septic patients with and without AKI. Median serum creatinine levels did not show significant differences between AKI and non-AKI patients. CONCLUSIONS: uNGAL, sCysC and uCysC were not altered by sepsis and were good predictors of AKI. In a septic state, sNGAL alone did not discriminate patients with AKI from those without AKI.
BACKGROUND/AIMS: We hypothesized that sepsis could have an impact on the sensitivity of serum and urinary neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (CysC) for acute kidney injury (AKI) diagnosis in critically ill children. METHODS: Serum NGAL (sNGAL) and urinary NGAL (uNGAL) and CysC were measured daily in the first 48 h from pediatric intensive care unit admission in 11 consecutive critically ill children with severe sepsis; a single measurement was made in a population of 10 healthy controls undergoing minor ambulatory surgery to exclude possible biases in the laboratory methods. RESULTS: uNGAL, serum CysC (sCysC), and urinary CysC (uCysC) levels were significantly increased in patients with septic AKI compared with septic patients without AKI, while sNGAL levels were not significantly different between septic patients with and without AKI. Median serum creatinine levels did not show significant differences between AKI and non-AKI patients. CONCLUSIONS: uNGAL, sCysC and uCysC were not altered by sepsis and were good predictors of AKI. In a septic state, sNGAL alone did not discriminate patients with AKI from those without AKI.
Authors: Sadudee Peerapornratana; Carlos L Manrique-Caballero; Hernando Gómez; John A Kellum Journal: Kidney Int Date: 2019-06-07 Impact factor: 10.612
Authors: Alexandra J M Zwiers; Saskia N de Wildt; Joost van Rosmalen; Yolanda B de Rijke; Erik A B Buijs; Dick Tibboel; Karlien Cransberg Journal: Crit Care Date: 2015-04-21 Impact factor: 9.097
Authors: James McCaffrey; Beatrice Coupes; Chris Chaloner; Nicholas J A Webb; Rachael Barber; Rachel Lennon Journal: Pediatr Nephrol Date: 2015-04-15 Impact factor: 3.714
Authors: Pieter A J G De Cock; Joseph F Standing; Charlotte I S Barker; Annick de Jaeger; Evelyn Dhont; Mieke Carlier; Alain G Verstraete; Joris R Delanghe; Hugo Robays; Peter De Paepe Journal: Antimicrob Agents Chemother Date: 2015-09-08 Impact factor: 5.191