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Literature DB >> 23428395

In and out of the bull's eye: protein kinase Cs in the immunological synapse.

Abstract

The immunological synapse (IS) formed between immune cells and antigen-presenting cells (APCs) provides a platform for signaling. Protein kinase C (PKC)θ localizes in the T cell IS within the central supramolecular activation cluster (cSMAC), where it associates with CD28 and mediates T cell receptor (TCR)/CD28 signals leading to effector T (Teff) cell activation. In regulatory T (Treg) cells, PKCθ is sequestered away from the IS, and inhibits suppressive function. Other PKCs localizing in the IS mediate additional functions in various immune cells. Further work is needed to identify mechanisms underlying PKC recruitment or exclusion at the IS, potential redundancy among IS-localized PKCs, and the relevance of PKC localization for IS dynamics and lymphocyte activation.

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Year: 2013 PMID： 23428395 PMCID： PMC3647024 DOI： 10.1016/j.it.2013.01.002

Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687

93 in total

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Authors: F Balamuth; D Leitenberg; J Unternaehrer; I Mellman; K Bottomly
Journal: Immunity Date: 2001-11 Impact factor: 31.745

3. Protein kinase C-theta mediates negative feedback on regulatory T cell function.

Authors: Alexandra Zanin-Zhorov; Yi Ding; Sudha Kumari; Mukundan Attur; Keli L Hippen; Maryanne Brown; Bruce R Blazar; Steven B Abramson; Juan J Lafaille; Michael L Dustin
Journal: Science Date: 2010-03-25 Impact factor: 47.728

4. Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytes.

Authors: Nikolaus Thuille; Isabelle Heit; Friedrich Fresser; Nina Krumböck; Birgit Bauer; Sabine Leuthaeusser; Sascha Dammeier; Caroline Graham; Terry D Copeland; Steve Shaw; Gottfried Baier
Journal: EMBO J Date: 2005-10-27 Impact factor: 11.598

5. Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster.

Authors: Santosha Vardhana; Kaushik Choudhuri; Rajat Varma; Michael L Dustin
Journal: Immunity Date: 2010-04-23 Impact factor: 31.745

6. Protein kinase Cθ C2 domain is a phosphotyrosine binding module that plays a key role in its activation.

Authors: Robert V Stahelin; Kok-Fai Kong; Sumita Raha; Wen Tian; Heather R Melowic; Katherine E Ward; Diana Murray; Amnon Altman; Wonhwa Cho
Journal: J Biol Chem Date: 2012-07-11 Impact factor: 5.157

7. T cell receptor signaling precedes immunological synapse formation.

Authors: Kyeong-Hee Lee; Amy D Holdorf; Michael L Dustin; Andrew C Chan; Paul M Allen; Andrey S Shaw
Journal: Science Date: 2002-02-22 Impact factor: 47.728

8. WIP is essential for lytic granule polarization and NK cell cytotoxicity.

Authors: Konrad Krzewski; Xi Chen; Jack L Strominger
Journal: Proc Natl Acad Sci U S A Date: 2008-02-07 Impact factor: 11.205

9. Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity.

Authors: Alberto Anel; Juan I Aguiló; Elena Catalán; Johan Garaude; Moeez G Rathore; Julián Pardo; Martín Villalba
Journal: Front Immunol Date: 2012-07-05 Impact factor: 7.561

10. Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells.

Authors: Christa Pfeifhofer; Kurt Kofler; Thomas Gruber; Nassim Ghaffari Tabrizi; Christina Lutz; Karl Maly; Michael Leitges; Gottfried Baier
Journal: J Exp Med Date: 2003-06-02 Impact factor: 14.307

16 in total

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Authors: Marion Dubuissez; Ingrid Loison; Sonia Paget; Han Vorng; Saliha Ait-Yahia; Olivier Rohr; Anne Tsicopoulos; Dominique Leprince
Journal: Mol Cell Biol Date: 2016-06-15 Impact factor: 4.272

2. Signal Transduction in Immune Cells and Protein Kinases.

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Journal: Adv Exp Med Biol Date: 2021 Impact factor: 2.622

Review 3. Protein kinase C in the immune system: from signalling to chromatin regulation.

Authors: Pek Siew Lim; Christopher Ray Sutton; Sudha Rao
Journal: Immunology Date: 2015-10-06 Impact factor: 7.397

4. Gnidimacrin, a Potent Anti-HIV Diterpene, Can Eliminate Latent HIV-1 Ex Vivo by Activation of Protein Kinase C β.

Authors: Weihong Lai; Li Huang; Lei Zhu; Guido Ferrari; Cliburn Chan; Wei Li; Kuo-Hsiung Lee; Chin-Ho Chen
Journal: J Med Chem Date: 2015-11-03 Impact factor: 7.446

5. The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease.

Authors: Cameron McDonald-Hyman; James T Muller; Michael Loschi; Govindarajan Thangavelu; Asim Saha; Sudha Kumari; Dawn K Reichenbach; Michelle J Smith; Guoan Zhang; Brent H Koehn; Jiqiang Lin; Jason S Mitchell; Brian T Fife; Angela Panoskaltsis-Mortari; Colby J Feser; Andrew Kemal Kirchmeier; Mark J Osborn; Keli L Hippen; Ameeta Kelekar; Jonathan S Serody; Laurence A Turka; David H Munn; Hongbo Chi; Thomas A Neubert; Michael L Dustin; Bruce R Blazar
Journal: J Clin Invest Date: 2018-08-14 Impact factor: 14.808

6. Immunostimulatory effects of RACK1 pseudosubstrate in human leukocytes obtained from young and old donors.

Authors: Emanuela Corsini; Valentina Galbiati; Antonella Pinto; Annalisa Davin; Letizia Polito; Antonio Guaita; Marco Racchi
Journal: Oncotarget Date: 2015-03-30

Review 7. The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency.

Authors: Stuart E Turvey; Anne Durandy; Alain Fischer; Shan-Yu Fung; Raif S Geha; Andreas Gewies; Thomas Giese; Johann Greil; Bärbel Keller; Margaret L McKinnon; Bénédicte Neven; Jacob Rozmus; Jürgen Ruland; Andrew L Snow; Polina Stepensky; Klaus Warnatz
Journal: J Allergy Clin Immunol Date: 2014-08 Impact factor: 10.793

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Authors: Vedran Brezar; Wen Juan Tu; Nabila Seddiki
Journal: Front Immunol Date: 2015-10-13 Impact factor: 7.561

9. Protein kinase C-η controls CTLA-4-mediated regulatory T cell function.

Authors: Kok-Fai Kong; Guo Fu; Yaoyang Zhang; Tadashi Yokosuka; Javier Casas; Ann J Canonigo-Balancio; Stephane Becart; Gisen Kim; John R Yates; Mitchell Kronenberg; Takashi Saito; Nicholas R J Gascoigne; Amnon Altman
Journal: Nat Immunol Date: 2014-04-06 Impact factor: 25.606

10. Nuclear PKC-θ facilitates rapid transcriptional responses in human memory CD4+ T cells through p65 and H2B phosphorylation.

Authors: Jasmine Li; Kristine Hardy; Chan Phetsouphanh; Wen Juan Tu; Elissa L Sutcliffe; Robert McCuaig; Christopher R Sutton; Anjum Zafar; C Mee Ling Munier; John J Zaunders; Yin Xu; Angelo Theodoratos; Abel Tan; Pek Siew Lim; Tobias Knaute; Antonia Masch; Johannes Zerweck; Vedran Brezar; Peter J Milburn; Jenny Dunn; Marco G Casarotto; Stephen J Turner; Nabila Seddiki; Anthony D Kelleher; Sudha Rao
Journal: J Cell Sci Date: 2016-05-05 Impact factor: 5.285