| Literature DB >> 23427096 |
Valentina Aina1, Giuseppina Cerrato, Gianmario Martra, Loredana Bergandi, Costanzo Costamagna, Dario Ghigo, Gianluca Malavasi, Gigliola Lusvardi, Ledi Menabue.
Abstract
A new melted bioactive system containing gold nanoparticles (AuNPs) was prepared exploiting a post-synthesis thermal treatment that allows one to modify crystal phases and nature, shape and distribution of the gold species in the glass-ceramic matrix as evidenced by UV-visible spectroscopy, transmission electron microscopy and powder X-ray diffraction analysis. In human MG-63 osteoblasts the presence of Au(n)(+) species caused an increase of lactate dehydrogenase leakage and malonyldialdehyde production, whereas Hench's Bioglass HAu-600-17 containing only AuNPs did not cause any effect. In addition, HAu-600-17 caused in vitro hydroxyapatite formation and an increase of specific surface area with a controlled release of gold species; this material is then suitable to be used as a model system for the controlled delivery of nanoparticles.Entities:
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Year: 2013 PMID： 23427096 PMCID： PMC3627079 DOI： 10.1098/rsif.2012.1040
Source DB: PubMed Journal: J R Soc Interface ISSN： 1742-5662 Impact factor: 4.118