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Literature DB >> 23423478

Site-specific conjugation of RAFT polymers to proteins via expressed protein ligation.

Yan Xia¹, Shengchang Tang, Bradley D Olsen.

Abstract

Site-specific protein conjugates with RAFT polymers were synthesized using expressed protein ligation. Stable micelles were formed from both linear block copolymer and Y-shaped conjugates.

Entities: Chemical Species

Mesh：

Substances：

Year: 2013 PMID： 23423478 PMCID： PMC4059823 DOI： 10.1039/c3cc38976f

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

19 in total

1. Versatile protein biotinylation strategies for potential high-throughput proteomics.

Authors: Rina Y P Lue; Grace Y J Chen; Yi Hu; Qing Zhu; Shao Q Yao
Journal: J Am Chem Soc Date: 2004-02-04 Impact factor: 15.419

2. Optimized conjugation of a fluorescent label to proteins via intein-mediated activation and ligation.

Authors: Robert J Wood; David D Pascoe; Zoë K Brown; Emma M Medlicott; Marco Kriek; Cameron Neylon; Peter L Roach
Journal: Bioconjug Chem Date: 2004 Mar-Apr Impact factor: 4.774

3. Temperature-regulated activity of responsive polymer-protein conjugates prepared by grafting-from via RAFT polymerization.

Authors: Priyadarsi De; Ming Li; Sudershan R Gondi; Brent S Sumerlin
Journal: J Am Chem Soc Date: 2008-07-30 Impact factor: 15.419

4. Emerging synthetic approaches for protein-polymer conjugations.

Authors: Rebecca M Broyer; Gregory N Grover; Heather D Maynard
Journal: Chem Commun (Camb) Date: 2011-01-12 Impact factor: 6.222

5. In situ growth of a PEG-like polymer from the C terminus of an intein fusion protein improves pharmacokinetics and tumor accumulation.

Authors: Weiping Gao; Wenge Liu; Trine Christensen; Michael R Zalutsky; Ashutosh Chilkoti
Journal: Proc Natl Acad Sci U S A Date: 2010-09-01 Impact factor: 11.205

Site-specific conjugation of RAFT polymers to proteins via expressed protein ligation.

1. Versatile protein biotinylation strategies for potential high-throughput proteomics.

2. Optimized conjugation of a fluorescent label to proteins via intein-mediated activation and ligation.

3. Temperature-regulated activity of responsive polymer-protein conjugates prepared by grafting-from via RAFT polymerization.

4. Emerging synthetic approaches for protein-polymer conjugations.

5. In situ growth of a PEG-like polymer from the C terminus of an intein fusion protein improves pharmacokinetics and tumor accumulation.

6. Polymeric dibromomaleimides as extremely efficient disulfide bridging bioconjugation and pegylation agents.

7. Phosphine-mediated one-pot thiol-ene "click" approach to polymer-protein conjugates.

8. Toward living radical polymerization.

9. Protein modification, bioconjugation, and disulfide bridging using bromomaleimides.

10. Bioorthogonal chemistry: fishing for selectivity in a sea of functionality.

1. Simple Protein Modification Using Zwitterionic Polymer to Mitigate the Bioactivity Loss of Conjugated Insulin.

2. Self-Assembly of Temperature-Responsive Protein-Polymer Bioconjugates.