Literature DB >> 23423437

Allosteric regulation of PKM2 allows cellular adaptation to different physiological states.

Dan Y Gui1, Caroline A Lewis, Matthew G Vander Heiden.   

Abstract

Pyruvate kinase isoform M2 (PKM2) activity is subject to complex allosteric regulation. Recently, serine and SAICAR (succinylaminoimidazolecarboxamide ribose-5'-phosphate) were identified as previously unrecognized activators of PKM2. These findings add additional complexity to how PKM2 is regulated in cells and support the notion that modulating PKM2 activity enables cells to adapt their metabolic state to specific physiological contexts.

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Year:  2013        PMID： 23423437     DOI： 10.1126/scisignal.2003925

Source DB:  PubMed          Journal:  Sci Signal        ISSN： 1945-0877            Impact factor:   8.192


  42 in total

1.  Purification and Characterization of Prolyl Hydroxylase 3/Pyruvate Kinase Isoform 2 Protein Complex.

Authors:  Sunil Kumar; Ashok Kumar Patel
Journal:  Mol Biotechnol       Date:  2020-02       Impact factor: 2.695

2.  Electrophilic Modification of PKM2 by 4-Hydroxynonenal and 4-Oxononenal Results in Protein Cross-Linking and Kinase Inhibition.

Authors:  Jeannie M Camarillo; Jody C Ullery; Kristie L Rose; Lawrence J Marnett
Journal:  Chem Res Toxicol       Date:  2017-01-03       Impact factor: 3.739

3.  Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity.

Authors:  Vivian M Liu; Andrea J Howell; Aaron M Hosios; Zhaoqi Li; William J Israelsen; Matthew G Vander Heiden
Journal:  FEBS Lett       Date:  2019-11-16       Impact factor: 4.124

Review 4.  Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?

Authors:  R Brooks Robey; Judith Weisz; Nancy B Kuemmerle; Anna C Salzberg; Arthur Berg; Dustin G Brown; Laura Kubik; Roberta Palorini; Fahd Al-Mulla; Rabeah Al-Temaimi; Annamaria Colacci; Chiara Mondello; Jayadev Raju; Jordan Woodrick; A Ivana Scovassi; Neetu Singh; Monica Vaccari; Rabindra Roy; Stefano Forte; Lorenzo Memeo; Hosni K Salem; Amedeo Amedei; Roslida A Hamid; Graeme P Williams; Leroy Lowe; Joel Meyer; Francis L Martin; William H Bisson; Ferdinando Chiaradonna; Elizabeth P Ryan
Journal:  Carcinogenesis       Date:  2015-06       Impact factor: 4.944

5.  O-GlcNAcylation destabilizes the active tetrameric PKM2 to promote the Warburg effect.

Authors:  Yang Wang; Jia Liu; Xin Jin; Dapeng Zhang; Dongxue Li; Fengqi Hao; Yunpeng Feng; Shan Gu; Fanlin Meng; Miaomiao Tian; Yi Zheng; Ling Xin; Xinbo Zhang; Xue Han; L Aravind; Min Wei
Journal:  Proc Natl Acad Sci U S A       Date:  2017-12-11       Impact factor: 11.205

6.  Allosteric targeting of receptor tyrosine kinases.

Authors:  Frederik De Smet; Arthur Christopoulos; Peter Carmeliet
Journal:  Nat Biotechnol       Date:  2014-11       Impact factor: 54.908

7.  Evaluation of Glycolytic Response to Multiple Classes of Anti-glioblastoma Drugs by Noninvasive Measurement of Pyruvate Kinase M2 Using [18F]DASA-23.

Authors:  Corinne Beinat; Chirag B Patel; Yuanyang Xie; Sanjiv S Gambhir
Journal:  Mol Imaging Biol       Date:  2020-02       Impact factor: 3.488

8.  Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation.

Authors:  Sophia Y Lunt; Vinayak Muralidhar; Aaron M Hosios; William J Israelsen; Dan Y Gui; Lauren Newhouse; Martin Ogrodzinski; Vivian Hecht; Kali Xu; Paula N Marín Acevedo; Daniel P Hollern; Gary Bellinger; Talya L Dayton; Stefan Christen; Ilaria Elia; Anh T Dinh; Gregory Stephanopoulos; Scott R Manalis; Michael B Yaffe; Eran R Andrechek; Sarah-Maria Fendt; Matthew G Vander Heiden
Journal:  Mol Cell       Date:  2014-12-04       Impact factor: 17.970

9.  Elaboration of the Corticosteroid Synthesis Pathway in Primates through a Multistep Enzyme.

Authors:  Carrie F Olson-Manning
Journal:  Mol Biol Evol       Date:  2020-08-01       Impact factor: 16.240

Review 10.  Tumor pyruvate kinase M2 modulators: a comprehensive account of activators and inhibitors as anticancer agents.

Authors:  Bhagyashri Rathod; Shivam Chak; Sagarkumar Patel; Amit Shard
Journal:  RSC Med Chem       Date:  2021-05-17
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