Literature DB >> 23423192

Protein corona significantly reduces active targeting yield.

Vahid Mirshafiee1, Morteza Mahmoudi, Kaiyan Lou, Jianjun Cheng, Mary L Kraft.   

Abstract

When nanoparticles (NPs) are exposed to the biological environment, their surfaces become covered with proteins and biomolecules (e.g. lipids). Here, we report that this protein coating, or corona, reduces the targeting capability of surface engineered NPs by screening the active sites of the targeting ligands.

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Year:  2013        PMID： 23423192      PMCID： PMC3671387          DOI： 10.1039/c3cc37307j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  18 in total

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