BACKGROUND: We previously reported that when compared with controls, long-term abstinent alcoholics (LTAA) have increased resting-state synchrony (RSS) of the inhibitory control network and reduced synchrony of the appetitive drive network, and hypothesized that these levels of synchrony are adaptive and support the behavioral changes required to maintain abstinence. In this study, we investigate whether these RSS patterns can be identified in short-term abstinent alcoholics (STAA). METHODS: Resting-state functional magnetic resonance imaging data were collected from 27 STAA, 23 LTAA, and 23 nonsubstance abusing controls (NSAC). We examined baseline RSS using seed-based measures. RESULTS: We found ordered RSS effects from NSAC to STAA and then to LTAA within both the appetitive drive and executive control networks: increasing RSS of the executive control network and decreasing RSS of the reward processing network. Finally, we found significant correlations between strength of RSS in these networks and (i) cognitive flexibility, and (ii) current antisocial behavior. CONCLUSIONS: Findings are consistent with an adaptive progression of RSS from short- to long-term abstinence, so that, compared with normal controls, the synchrony (i) within the reward network progressively decreases, and (ii) within the executive control network progressively increases.
BACKGROUND: We previously reported that when compared with controls, long-term abstinent alcoholics (LTAA) have increased resting-state synchrony (RSS) of the inhibitory control network and reduced synchrony of the appetitive drive network, and hypothesized that these levels of synchrony are adaptive and support the behavioral changes required to maintain abstinence. In this study, we investigate whether these RSS patterns can be identified in short-term abstinent alcoholics (STAA). METHODS: Resting-state functional magnetic resonance imaging data were collected from 27 STAA, 23 LTAA, and 23 nonsubstance abusing controls (NSAC). We examined baseline RSS using seed-based measures. RESULTS: We found ordered RSS effects from NSAC to STAA and then to LTAA within both the appetitive drive and executive control networks: increasing RSS of the executive control network and decreasing RSS of the reward processing network. Finally, we found significant correlations between strength of RSS in these networks and (i) cognitive flexibility, and (ii) current antisocial behavior. CONCLUSIONS: Findings are consistent with an adaptive progression of RSS from short- to long-term abstinence, so that, compared with normal controls, the synchrony (i) within the reward network progressively decreases, and (ii) within the executive control network progressively increases.
Authors: Stephen M Smith; Mark Jenkinson; Mark W Woolrich; Christian F Beckmann; Timothy E J Behrens; Heidi Johansen-Berg; Peter R Bannister; Marilena De Luca; Ivana Drobnjak; David E Flitney; Rami K Niazy; James Saunders; John Vickers; Yongyue Zhang; Nicola De Stefano; J Michael Brady; Paul M Matthews Journal: Neuroimage Date: 2004 Impact factor: 6.556
Authors: Robert E Kelly; George S Alexopoulos; Zhishun Wang; Faith M Gunning; Christopher F Murphy; Sarah Shizuko Morimoto; Dora Kanellopoulos; Zhiru Jia; Kelvin O Lim; Matthew J Hoptman Journal: J Neurosci Methods Date: 2010-04-08 Impact factor: 2.390
Authors: Simon Zhornitsky; Sheng Zhang; Jaime S Ide; Herta H Chao; Wuyi Wang; Thang M Le; Robert F Leeman; Jinbo Bi; John H Krystal; Chiang-Shan R Li Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2018-12-12
Authors: Simon Zhornitsky; Jaime S Ide; Wuyi Wang; Herta H Chao; Sheng Zhang; Sien Hu; John H Krystal; Chiang-Shan R Li Journal: Brain Connect Date: 2018-10
Authors: A Correas; E López-Caneda; L Beaton; S Rodríguez Holguín; L M García-Moreno; L F Antón-Toro; F Cadaveira; F Maestú; K Marinkovic Journal: J Psychopharmacol Date: 2018-10-24 Impact factor: 4.153