Smooth muscle cell Ca²⁺: think locally, act globally.

Dynamic changes in intracellular Ca²⁺ levels in vascular smooth muscle cells are critically important for cardiovascular regulation. This Special Topic Issue highlights a series of expert opinion articles focused on this important subject. After a brief overview, novel discoveries surrounding smooth muscle cell Ca²⁺ influx via L-type and T-type channels are reviewed. Current work revealing the functional importance of dynamic Ca²⁺ signaling in the control of the parenchymal microvasculature and the emerging role of mitochondrial Ca²⁺ signaling and store-operated Ca²⁺ entry in smooth muscle cells is discussed. Finally, recent data describing a new target of localized Ca²⁺ signaling in arterial myocytes that is responsible for membrane depolarization is reviewed. Authors were encouraged to write in an opinionated and provocative manner with the hope of stimulating discussion in this area of research.