Literature DB >> 2342053

Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site.

M F Hibert1, R Hoffmann, R C Miller, A A Carr.   

Abstract

A conformation-activity relationship study of 5-HT3 receptor antagonists was used to define a pharmacophore and receptor map to qualitatively account for their activity. The design and synthesis of specific keto-amino-indole derivatives that are potent 5-HT3 receptor antagonists gave some support to the model.

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Year:  1990        PMID： 2342053     DOI： 10.1021/jm00168a011

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  13 in total

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