Literature DB >> 23420121

A novel near-infrared fluorescent probe for selectively sensing nitroreductase (NTR) in an aqueous medium.

Youmin Shi1, Sichun Zhang, Xinrong Zhang.   

Abstract

A novel near-infrared (NIR) fluorescent probe based on cyanine dyes was designed and synthesized to detect nitroreductase (NTR) activity. Upon reaction with NTR, the nitro-group of p-nitrobenzyl moiety was reduced to amino-group and therefore renews the π-electron conjugation of the dye, resulting in the intense NIR fluorescent emission (708 nm). This redox-induced NIR-fluorescence probe has been successfully applied to the detection of NTR activity under physiological conditions with high selectivity.

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Year:  2013        PMID： 23420121     DOI： 10.1039/c3an36807f

Source DB:  PubMed          Journal:  Analyst        ISSN： 0003-2654            Impact factor:   4.616


  9 in total

1.  Synthesis and use of QCy7-derived modular probes for the detection and imaging of biologically relevant analytes.

Authors:  Orit Redy-Keisar; Einat Kisin-Finfer; Shiran Ferber; Ronit Satchi-Fainaro; Doron Shabat
Journal:  Nat Protoc       Date:  2013-12-05       Impact factor: 13.491

Review 2.  Cyanine polyene reactivity: scope and biomedical applications.

Authors:  Alexander P Gorka; Roger R Nani; Martin J Schnermann
Journal:  Org Biomol Chem       Date:  2015-07-28       Impact factor: 3.876

3.  Coumarin-based fluorescent 'AND' logic gate probes for the detection of homocysteine and a chosen biological analyte.

Authors:  Luling Wu; Jordan E Gardiner; Lokesh K Kumawat; Hai-Hao Han; Ruiying Guo; Xin Li; Xiao-Peng He; Robert B P Elmes; Adam C Sedgwick; Steven D Bull; Tony D James
Journal:  RSC Adv       Date:  2019-08-27       Impact factor: 4.036

4.  A self-immolative linker that releases thiols detects penicillin amidase and nitroreductase with high sensitivity via absorption spectroscopy.

Authors:  Eli M Espinoza; Joachim J Røise; Maomao He; I-Che Li; Alvin K Agatep; Patrick Udenyi; Hesong Han; Nicole Jackson; D Lucas Kerr; Dake Chen; Michael R Stentzel; Emily Ruan; Lee Riley; Niren Murthy
Journal:  Chem Commun (Camb)       Date:  2022-03-03       Impact factor: 6.065

5.  Long-wavelength analyte-sensitive luminescent probes and optical (bio)sensors.

Authors:  Christoph Staudinger; Sergey M Borisov
Journal:  Methods Appl Fluoresc       Date:  2015-10-22       Impact factor: 3.009

6.  Development of a Bioluminescent Nitroreductase Probe for Preclinical Imaging.

Authors:  Anzhelika G Vorobyeva; Michael Stanton; Aurélien Godinat; Kjetil B Lund; Grigory G Karateev; Kevin P Francis; Elizabeth Allen; Juri G Gelovani; Emmet McCormack; Mark Tangney; Elena A Dubikovskaya
Journal:  PLoS One       Date:  2015-06-25       Impact factor: 3.240

7.  Hypoxia imaging in cells and tumor tissues using a highly selective fluorescent nitroreductase probe.

Authors:  Dan Yang; Hang Yu Tian; Tie Nan Zang; Ming Li; Ying Zhou; Jun Feng Zhang
Journal:  Sci Rep       Date:  2017-08-23       Impact factor: 4.379

8.  A novel nitroreductase-enhanced MRI contrast agent and its potential application in bacterial imaging.

Authors:  Yun Liu; Leilei Zhang; Marc Nazare; Qingqiang Yao; Hai-Yu Hu
Journal:  Acta Pharm Sin B       Date:  2017-12-06       Impact factor: 11.413

9.  Bioinspired large Stokes shift small molecular dyes for biomedical fluorescence imaging.

Authors:  Hao Chen; Lingjun Liu; Kun Qian; Hailong Liu; Zhiming Wang; Feng Gao; Chunrong Qu; Wenhao Dai; Daizong Lin; Kaixian Chen; Hong Liu; Zhen Cheng
Journal:  Sci Adv       Date:  2022-08-12       Impact factor: 14.957
  9 in total

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