| Literature DB >> 23419525 |
Mark Katakowski1, Ben Buller, Xuguang Zheng, Yong Lu, Thomas Rogers, Oyinkansola Osobamiro, Wayne Shu, Feng Jiang, Michael Chopp.
Abstract
Exosomes are 30-150 nm vesicles secreted by a wide range of mammalian cells that can contain microRNA (miRNA). To test if marrow stromal cell (MSC) exosomes could be used as a vehicle for delivery of anti-tumor miRNAs, we transfected MSCs with a miR-146b expression plasmid, and harvested exosomes released by the MSCs. Intra-tumor injection of exosomes derived from miR-146-expressing MSCs significantly reduced glioma xenograft growth in a rat model of primary brain tumor.Entities:
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Year: 2013 PMID： 23419525 PMCID： PMC3665755 DOI： 10.1016/j.canlet.2013.02.019
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679