Literature DB >> 23419040

Toll-like receptors in neonatal sepsis.

Fiona M O'Hare1, R William Watson, Eleanor J Molloy.   

Abstract

UNLABELLED: Toll-like receptors are vital transmembrane receptors that initiate the innate immune response to many micro-organisms. The discovery of these receptors has improved our understanding of host-pathogen interactions, and these receptors play an important role in the pathogenesis of multiple neonatal conditions such as sepsis and brain injury. Toll-like receptors, especially TLRs 2 and 4, are associated with necrotizing enterocolitis, periventricular leukomalacia and sepsis.
CONCLUSION: Toll-like receptor modulation may potentially be used as immunomodulators in the management of neonatal sepsis. ©2013 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

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Year:  2013        PMID： 23419040     DOI： 10.1111/apa.12201

Source DB:  PubMed          Journal:  Acta Paediatr        ISSN： 0803-5253            Impact factor:   2.299


  6 in total

1.  Regulatory T cell frequencies are increased in preterm infants with clinical early-onset sepsis.

Authors:  J Pagel; A Hartz; J Figge; C Gille; S Eschweiler; K Petersen; L Schreiter; J Hammer; C M Karsten; D Friedrich; E Herting; W Göpel; J Rupp; C Härtel
Journal:  Clin Exp Immunol       Date:  2016-06-12       Impact factor: 4.330

2.  Vitamin D enhances reactive oxygen intermediates production in phagocytic cells in term and preterm infants.

Authors:  Chike Onwuneme; Alfonso Blanco; Amanda O'Neill; Bill Watson; Eleanor J Molloy
Journal:  Pediatr Res       Date:  2015-12-21       Impact factor: 3.756

3.  Acute LPS sensitization and continuous infusion exacerbates hypoxic brain injury in a piglet model of neonatal encephalopathy.

Authors:  Kathryn A Martinello; Christopher Meehan; Adnan Avdic-Belltheus; Ingran Lingam; Sara Ragab; Mariya Hristova; Cally J Tann; Donald Peebles; Henrik Hagberg; Tim G A M Wolfs; Nigel Klein; Ilias Tachtsidis; Xavier Golay; Boris W Kramer; Bobbi Fleiss; Pierre Gressens; Nicola J Robertson
Journal:  Sci Rep       Date:  2019-07-15       Impact factor: 4.379

Review 4.  Neonates and COVID-19: state of the art : Neonatal Sepsis series.

Authors:  L Ryan; Frans B Plötz; Agnes van den Hoogen; Jos M Latour; Marina Degtyareva; Maya Keuning; Claus Klingenberg; Irwin K M Reiss; Eric Giannoni; Charles Roehr; Christopher Gale; Eleanor J Molloy
Journal:  Pediatr Res       Date:  2021-12-28       Impact factor: 3.953

5.  Increased Regulatory T Cells Precede the Development of Bronchopulmonary Dysplasia in Preterm Infants.

Authors:  Julia Pagel; Nele Twisselmann; Tanja K Rausch; Silvio Waschina; Annika Hartz; Magdalena Steinbeis; Jonathan Olbertz; Kathrin Nagel; Alena Steinmetz; Kirstin Faust; Martin Demmert; Wolfgang Göpel; Egbert Herting; Jan Rupp; Christoph Härtel
Journal:  Front Immunol       Date:  2020-09-30       Impact factor: 7.561

6.  The ACE2-Ang-(1‑7)-Mas Axis Modulates M1/M2 Macrophage Polarization to Relieve CLP-Induced Inflammation via TLR4-Mediated NF-кb and MAPK Pathways.

Authors:  Hang Pan; Wenhan Huang; Zhongjie Wang; Feifeng Ren; Lei Luo; Jun Zhou; Mengxue Tian; Lin Tang
Journal:  J Inflamm Res       Date:  2021-05-20
  6 in total

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