OBJECTIVE: To date, the impact of the neurotransmitter serotonin (5-HT) on different neuropsychological functions in adults with attention deficit hyperactivity disorder (ADHD) is underinvestigated. We aimed to examine the effects of acute tryptophan depletion (ATD) and the resulting reduction in central nervous 5-HT synthesis on target/non-target discrimination ability and sustained attention in adults with ADHD using an AX-Continuous Performance Test (AX-CPT). METHOD: Twenty male patients with ADHD (age: M = 30.25 SD = 9.37) and twenty male healthy controls (age: M = 27.90 SD = 6.01) received ATD on one day and a tryptophan-balanced control condition (BAL) on another day in a double-blind within-subject crossover design. A continuous performance test (AX-CPT) with three conditions (AX, AY, and BX) was administered on both days under depleted and sham-depleted conditions. RESULTS: In patients omissions increased after ATD when compared with BAL. Patient's reaction time decreased after ATD when compared with BAL, which was contrasted by opposite effects in controls. Patients showed fewer correct responses (AX condition) and showed a higher rate of errors (condition AXE ) independent of ATD or BAL intake. CONCLUSION: The present preliminary results are indicative of the contribution of serotonergic neurotransmission to attentional processes in adults with ADHD.
RCT Entities:
OBJECTIVE: To date, the impact of the neurotransmitter serotonin (5-HT) on different neuropsychological functions in adults with attention deficit hyperactivity disorder (ADHD) is underinvestigated. We aimed to examine the effects of acute tryptophan depletion (ATD) and the resulting reduction in central nervous 5-HT synthesis on target/non-target discrimination ability and sustained attention in adults with ADHD using an AX-Continuous Performance Test (AX-CPT). METHOD: Twenty male patients with ADHD (age: M = 30.25 SD = 9.37) and twenty male healthy controls (age: M = 27.90 SD = 6.01) received ATD on one day and a tryptophan-balanced control condition (BAL) on another day in a double-blind within-subject crossover design. A continuous performance test (AX-CPT) with three conditions (AX, AY, and BX) was administered on both days under depleted and sham-depleted conditions. RESULTS: In patients omissions increased after ATD when compared with BAL. Patient's reaction time decreased after ATD when compared with BAL, which was contrasted by opposite effects in controls. Patients showed fewer correct responses (AX condition) and showed a higher rate of errors (condition AXE ) independent of ATD or BAL intake. CONCLUSION: The present preliminary results are indicative of the contribution of serotonergic neurotransmission to attentional processes in adults with ADHD.
Authors: S Neufang; A Akhrif; C G Herrmann; C Drepper; G A Homola; J Nowak; J Waider; A G Schmitt; K-P Lesch; M Romanos Journal: Transl Psychiatry Date: 2016-11-08 Impact factor: 6.222
Authors: Stephen H Boyle; Beverly H Brummett; Cynthia M Kuhn; John C Barefoot; Ilene C Siegler; Redford B Williams; Anastasia Georgiades Journal: Psychosom Med Date: 2019-01 Impact factor: 4.312
Authors: William E Shell; Stephanie Pavlik; Brandon Roth; Michael Silver; Mira L Breitstein; Lawrence May; David Silver Journal: Am J Ther Date: 2016 Nov/Dec Impact factor: 2.688
Authors: A Merchán; S V Navarro; A B Klein; S Aznar; L Campa; C Suñol; M Moreno; P Flores Journal: Psychopharmacology (Berl) Date: 2017-03-09 Impact factor: 4.530
Authors: Christian Mette; Marco Grabemann; Marco Zimmermann; Laura Strunz; Norbert Scherbaum; Jens Wiltfang; Bernhard Kis Journal: PLoS One Date: 2015-07-29 Impact factor: 3.240
Authors: Tilman J Gaber; Vita L S Dingerkus; Molly J Crockett; Sarah Bubenzer-Busch; Katrin Helmbold; Cristina L Sánchez; Brigitte Dahmen; Beate Herpertz-Dahlmann; Florian D Zepf Journal: Food Nutr Res Date: 2015-08-11 Impact factor: 3.894