BACKGROUND: Acrylamide is a probable human carcinogen formed during cooking of starchy foods. Two large prospective cohort studies of dietary acrylamide intake and ovarian cancer risk observed a positive association, although two other studies reported no association. METHODS: We measured acrylamide exposure using red blood cell acrylamide and glycidamide hemoglobin adducts among women in two large prospective cohorts: the Nurses' Health Study and Nurses' Health Study II. Between blood collection and 2010, we identified 263 incident cases of epithelial ovarian cancer, matching two controls per case. We used logistic regression models to examine the association between acrylamide exposure and ovarian cancer risk, adjusting for matching factors, family history of ovarian cancer, tubal ligation, oral contraceptive use, body mass index, parity, alcohol intake, smoking, physical activity, and caffeine intake. RESULTS: The multivariate-adjusted relative risk (RR) of ovarian cancer comparing the highest versus lowest tertile of total acrylamide adducts was 0.79 (95% CI, 0.50-1.24, P trend = 0.08). The comparable RR of ovarian cancer among non-smokers at blood draw was 0.85 (95% CI, 0.57-1.27, P trend = 0.14). The association did not differ by tumor histology (serous invasive versus not), P for heterogeneity = 0.86. Individual adduct types (acrylamide or glycidamide) were not associated with risk. CONCLUSIONS: We observed no evidence that acrylamide exposure as measured by adducts to hemoglobin is associated with an increased risk of ovarian cancer. IMPACT: Our finding indicates that acrylamide intake may not increase risk of ovarian cancer.
BACKGROUND:Acrylamide is a probable human carcinogen formed during cooking of starchy foods. Two large prospective cohort studies of dietary acrylamide intake and ovarian cancer risk observed a positive association, although two other studies reported no association. METHODS: We measured acrylamide exposure using red blood cell acrylamide and glycidamide hemoglobin adducts among women in two large prospective cohorts: the Nurses' Health Study and Nurses' Health Study II. Between blood collection and 2010, we identified 263 incident cases of epithelial ovarian cancer, matching two controls per case. We used logistic regression models to examine the association between acrylamide exposure and ovarian cancer risk, adjusting for matching factors, family history of ovarian cancer, tubal ligation, oral contraceptive use, body mass index, parity, alcohol intake, smoking, physical activity, and caffeine intake. RESULTS: The multivariate-adjusted relative risk (RR) of ovarian cancer comparing the highest versus lowest tertile of total acrylamide adducts was 0.79 (95% CI, 0.50-1.24, P trend = 0.08). The comparable RR of ovarian cancer among non-smokers at blood draw was 0.85 (95% CI, 0.57-1.27, P trend = 0.14). The association did not differ by tumor histology (serous invasive versus not), P for heterogeneity = 0.86. Individual adduct types (acrylamide or glycidamide) were not associated with risk. CONCLUSIONS: We observed no evidence that acrylamide exposure as measured by adducts to hemoglobin is associated with an increased risk of ovarian cancer. IMPACT: Our finding indicates that acrylamide intake may not increase risk of ovarian cancer.
Authors: M J Stampfer; W C Willett; F E Speizer; D C Dysert; R Lipnick; B Rosner; C H Hennekens Journal: Am J Epidemiol Date: 1984-05 Impact factor: 4.897
Authors: K A Johnson; S J Gorzinski; K M Bodner; R A Campbell; C H Wolf; M A Friedman; R W Mast Journal: Toxicol Appl Pharmacol Date: 1986-09-15 Impact factor: 4.219
Authors: S E Hankinson; W C Willett; J E Manson; D J Hunter; G A Colditz; M J Stampfer; C Longcope; F E Speizer Journal: J Natl Cancer Inst Date: 1995-09-06 Impact factor: 13.506
Authors: Andrea Hartwig; Michael Arand; Bernd Epe; Sabine Guth; Gunnar Jahnke; Alfonso Lampen; Hans-Jörg Martus; Bernhard Monien; Ivonne M C M Rietjens; Simone Schmitz-Spanke; Gerlinde Schriever-Schwemmer; Pablo Steinberg; Gerhard Eisenbrand Journal: Arch Toxicol Date: 2020-06-15 Impact factor: 5.153
Authors: Janneke G Hogervorst; Renee T Fortner; Lorelei A Mucci; Shelley S Tworoger; A Heather Eliassen; Susan E Hankinson; Kathryn M Wilson Journal: Cancer Epidemiol Biomarkers Prev Date: 2013-08-27 Impact factor: 4.254
Authors: Mireia Obón-Santacana; Heinz Freisling; Petra H Peeters; Leila Lujan-Barroso; Pietro Ferrari; Marie-Christine Boutron-Ruault; Sylvie Mesrine; Laura Baglietto; Renee Turzanski-Fortner; Verena A Katzke; Heiner Boeing; J Ramón Quirós; Elena Molina-Portillo; Nerea Larrañaga; María-Dolores Chirlaque; Aurelio Barricarte; Kay-Tee Khaw; Nick Wareham; Ruth C Travis; Melissa A Merritt; Marc J Gunter; Antonia Trichopoulou; Pagona Lagiou; Androniki Naska; Domenico Palli; Sabina Sieri; Rosario Tumino; Valentina Fiano; Rocco Galassom; H B As Bueno-de-Mesquita; N Charlotte Onland-Moret; Annika Idahl; Eva Lundin; Elisabete Weiderpass; Hubert Vesper; Elio Riboli; Eric J Duell Journal: Int J Cancer Date: 2015-10-01 Impact factor: 7.396
Authors: Janneke G F Hogervorst; Piet A van den Brandt; Roger W L Godschalk; Frederik-Jan van Schooten; Leo J Schouten Journal: Eur J Epidemiol Date: 2017-04-08 Impact factor: 8.082
Authors: Mireia Obón-Santacana; Leila Lujan-Barroso; Ruth C Travis; Heinz Freisling; Pietro Ferrari; Gianluca Severi; Laura Baglietto; Marie-Christine Boutron-Ruault; Renée T Fortner; Jennifer Ose; Heiner Boeing; Virginia Menéndez; Emilio Sánchez-Cantalejo; Saioa Chamosa; José María Huerta Castaño; Eva Ardanaz; Kay-Tee Khaw; Nick Wareham; Melissa A Merritt; Marc J Gunter; Antonia Trichopoulou; Eleni-Maria Papatesta; Eleni Klinaki; Calogero Saieva; Giovanna Tagliabue; Rosario Tumino; Carlotta Sacerdote; Amalia Mattiello; H B Bueno-de-Mesquita; Petra H Peeters; N Charlotte Onland-Moret; Annika Idahl; Eva Lundin; Elisabete Weiderpass; Hubert W Vesper; Elio Riboli; Eric J Duell Journal: Cancer Epidemiol Biomarkers Prev Date: 2015-11-23 Impact factor: 4.254
Authors: Mireia Obón-Santacana; Petra H M Peeters; Heinz Freisling; Laure Dossus; Françoise Clavel-Chapelon; Laura Baglietto; Helena Schock; Renée T Fortner; Heiner Boeing; Anne Tjønneland; Anja Olsen; Kim Overvad; Virginia Menéndez; Maria-José Sanchez; Nerea Larrañaga; José María Huerta Castaño; Aurelio Barricarte; Kay-Tee Khaw; Nick Wareham; Ruth C Travis; Melissa A Merritt; Antonia Trichopoulou; Dimitrios Trichopoulos; Philippos Orfanos; Giovanna Masala; Sabina Sieri; Rosario Tumino; Paolo Vineis; Amalia Mattiello; H B Bueno-de-Mesquita; N Charlotte Onland-Moret; Elisabeth Wirfält; Tanja Stocks; Annika Idahl; Eva Lundin; Guri Skeie; Inger T Gram; Elisabete Weiderpass; Elio Riboli; Eric J Duell Journal: Cancer Epidemiol Biomarkers Prev Date: 2014-10-09 Impact factor: 4.254