Bench to bedside: new developments in our understanding of the pathophysiology of thrombosis.

There has been a resurgent interest in the molecular and cellular mechanisms of thrombogenesis in venous thromboembolism (VTE). Improved animal models of VTE, combined with high-resolution microscopy techniques, have helped to uncover novel roles for blood cells including platelets and innate immune cells, particularly neutrophils. These insights are likely to result in novel disease biomarkers and perhaps even adjunctive anti-thrombotic therapies.