Literature DB >> 23416971

Aptamer-targeted hyperbranched polymers: towards greater specificity for tumours in vivo.

Daniel J Coles1, Barbara E Rolfe, Nathan R B Boase, Rakesh N Veedu, Kristofer J Thurecht.   

Abstract

Hyperbranched polymers conjugated to a peptide-aptamer were prepared using a combination of RAFT polymerisation and click chemistry for targeting tumour cells in vivo. The polymers showed enhanced cell-uptake in vitro (compared to unconjugated polymer) while excellent specificity for solid tumours was observed in vivo using a mouse model of melanoma.

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Year:  2013        PMID： 23416971     DOI： 10.1039/c3cc00127j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

Review 1.  Development of individualized anti-metastasis strategies by engineering nanomedicines.

Authors:  Qianjun He; Shengrong Guo; Zhiyong Qian; Xiaoyuan Chen
Journal:  Chem Soc Rev       Date:  2015-06-09       Impact factor: 54.564

Review 2.  Targeting Nanomedicines to Prostate Cancer: Evaluation of Specificity of Ligands to Two Different Receptors In Vivo.

Authors:  Amanda K Pearce; Adrian V Fuchs; Nicholas L Fletcher; Kristofer J Thurecht
Journal:  Pharm Res       Date:  2016-05-25       Impact factor: 4.200

3.  Aptamer-polymer functionalized silicon nanosubstrates for enhanced recovered circulating tumor cell viability and in vitro chemosensitivity testing.

Authors:  Qinglin Shen; Caixia Peng; Yan Zhan; Liang Fan; Mengyi Wang; Qing Zhou; Jue Liu; Xiaojuan Lv; Qiu Tang; Jun Li; Xiaodong Huang; Jiahong Xia
Journal:  Int J Nanomedicine       Date:  2016-05-18

Review 4.  Nucleic Acid Aptamers: Emerging Applications in Medical Imaging, Nanotechnology, Neurosciences, and Drug Delivery.

Authors:  Pascal Röthlisberger; Cécile Gasse; Marcel Hollenstein
Journal:  Int J Mol Sci       Date:  2017-11-16       Impact factor: 5.923

5.  A Hyperfluorinated Hydrophilic Molecule for Aqueous 19F MRI Contrast Media.

Authors:  Eric A Tanifum; Laxman Devkota; Conelius Ngwa; Andrew A Badachhape; Ketan B Ghaghada; Jonathan Romero; Robia G Pautler; Ananth V Annapragada
Journal:  Contrast Media Mol Imaging       Date:  2018-11-12       Impact factor: 3.161

6.  In vivo therapeutic evaluation of polymeric nanomedicines: effect of different targeting peptides on therapeutic efficacy against breast cancer.

Authors:  Yongmei Zhao; Nicholas L Fletcher; Tianqing Liu; Anna C Gemmell; Zachary H Houston; Idriss Blakey; Kristofer J Thurecht
Journal:  Nanotheranostics       Date:  2018-08-24
  6 in total

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