BACKGROUND: S-Nitrosoglutathione (GSNO) is the S-nitrosated derivative of glutathione and is thought to be a critical mediator of the down stream signaling effects of nitric oxide (NO). GSNO has also been implicated as a contributor to various disease states. SCOPE OF REVIEW: This review focuses on the chemical nature of GSNO, its biological activities, the evidence that it is an endogenous mediator of NO action, and implications for therapeutic use. MAJOR CONCLUSIONS: GSNO clearly exerts its cellular actions through both NO- and S-nitrosation-dependent mechanisms; however, the chemical and biological aspects of this compound should be placed in the context of S-nitrosation as a whole. GENERAL SIGNIFICANCE: GSNO is a central intermediate in formation and degradation of cellular S-nitrosothiols with potential therapeutic applications; thus, it remains an important molecule of study. This article is part of a Special Issue entitled Cellular functions of glutathione.
BACKGROUND:S-Nitrosoglutathione (GSNO) is the S-nitrosated derivative of glutathione and is thought to be a critical mediator of the down stream signaling effects of nitric oxide (NO). GSNO has also been implicated as a contributor to various disease states. SCOPE OF REVIEW: This review focuses on the chemical nature of GSNO, its biological activities, the evidence that it is an endogenous mediator of NO action, and implications for therapeutic use. MAJOR CONCLUSIONS:GSNO clearly exerts its cellular actions through both NO- and S-nitrosation-dependent mechanisms; however, the chemical and biological aspects of this compound should be placed in the context of S-nitrosation as a whole. GENERAL SIGNIFICANCE: GSNO is a central intermediate in formation and degradation of cellular S-nitrosothiols with potential therapeutic applications; thus, it remains an important molecule of study. This article is part of a Special Issue entitled Cellular functions of glutathione.
Authors: L J Ignarro; B K Barry; D Y Gruetter; J C Edwards; E H Ohlstein; C A Gruetter; W H Baricos Journal: Biochem Biophys Res Commun Date: 1980-05-14 Impact factor: 3.575
Authors: Xunde Wang; Jose E Tanus-Santos; Christopher D Reiter; Andre Dejam; Sruti Shiva; Reginald D Smith; Neil Hogg; Mark T Gladwin Journal: Proc Natl Acad Sci U S A Date: 2004-07-16 Impact factor: 11.205
Authors: Kenny K K Chung; Bobby Thomas; Xiaojie Li; Olga Pletnikova; Juan C Troncoso; Laura Marsh; Valina L Dawson; Ted M Dawson Journal: Science Date: 2004-04-22 Impact factor: 47.728
Authors: Taiming Liu; Meijuan Zhang; Michael H Terry; Hobe Schroeder; Sean M Wilson; Gordon G Power; Qian Li; Trent E Tipple; Dan Borchardt; Arlin B Blood Journal: Nitric Oxide Date: 2018-02-08 Impact factor: 4.427
Authors: Megan E Douglass; Marcus J Goudie; Jitendra Pant; Priyadarshini Singha; Sean Hopkins; Ryan Devine; Chad W Schmiedt; Hitesh Handa Journal: ACS Appl Bio Mater Date: 2019-05-07