Literature DB >> 23415868

A competing risks analysis should report results on all cause-specific hazards and cumulative incidence functions.

Aurelien Latouche1, Arthur Allignol, Jan Beyersmann, Myriam Labopin, Jason P Fine.   

Abstract

Competing risks endpoints are frequently encountered in hematopoietic stem cell transplantation where patients are exposed to relapse and treatment-related mortality. Both cause-specific hazards and direct models for the cumulative incidence functions have been used for analyzing such competing risks endpoints. For both approaches, the popular models are of a proportional hazards type. Such models have been used for studying prognostic factors in acute and chronic leukemias. We argue that a complete understanding of the event dynamics requires that both hazards and cumulative incidence be analyzed side by side, and that this is generally the most rigorous scientific approach to analyzing competing risks data. That is, understanding the effects of covariates on cause-specific hazards and cumulative incidence functions go hand in hand. A case study illustrates our proposal.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID: 23415868     DOI: 10.1016/j.jclinepi.2012.09.017

Source DB:  PubMed          Journal:  J Clin Epidemiol        ISSN: 0895-4356            Impact factor:   6.437


  129 in total

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