| Literature DB >> 23415634 |
Hapuarachchige C Hapuarachchi1, Helen M L Oh, Tun Linn Thein, Kwoon-Yong Pok, Yee-Ling Lai, Li-Kiang Tan, Kim-Sung Lee, Yee-Sin Leo, Lee-Ching Ng.
Abstract
Neurological manifestations due to Dengue virus (DENV) infection are atypical and uncommon. Genomic information of clinically characterised, neurotrophic DENV in humans is extremely limited albeit their importance in deciphering the pathogenicity is substantial. Here, we report a rare case of fatal DENV-4 infection complicated with encephalitis and multi-organ failure. The clinical presentation was unusual due to its rapid onset of encephalitis despite a very low virus titre. Full genomes of serum and CSF-derived viruses shared 99.99% similarity, indicating the virus dissemination across blood-brain barrier. Even though virus genomes did not reveal any of the neurotrophic substitutions of DENV documented so far, case isolates possessed a combination of 8 novel amino acid alterations, predominantly distributed in non-structural genes of DENV-4.Entities:
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Year: 2013 PMID： 23415634 DOI： 10.1016/j.jcv.2012.12.021
Source DB: PubMed Journal: J Clin Virol ISSN： 1386-6532 Impact factor: 3.168