Literature DB >> 23415104

Function of chromatin structure and dynamics in DNA damage, repair and misrepair: γ-rays and protons in action.

Lucie Ježková1, Martin Falk, Iva Falková, Marie Davídková, Alena Bačíková, Lenka Štefančíková, Jana Vachelová, Anna Michaelidesová, Emilie Lukášová, Alla Boreyko, Evgeny Krasavin, Stanislav Kozubek.   

Abstract

According to their physical characteristics, protons and ion beams promise a revolution in cancer radiotherapy. Curing protocols however reflect rather the empirical knowledge than experimental data on DNA repair. This especially holds for the spatio-temporal organization of repair processes in the context of higher-order chromatin structure-the problematics addressed in this work. The consequences for the mechanism of chromosomal translocations are compared for gamma rays and proton beams.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  DNA double-strand breaks (DSBs); Formation of chromosomal translocations; Gamma rays and proton beams; Higher-order chromatin structure and DSB repair; γH2AX foci

Mesh：

Substances：

Year:  2013        PMID： 23415104     DOI： 10.1016/j.apradiso.2013.01.022

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  11 in total

1.  Nanodiamonds and nanoparticles as tumor cell radiosensitizers-promising results but an obscure mechanism of action.

Authors:  Martin Falk
Journal:  Ann Transl Med       Date:  2017-01

Review 2.  Opportunities and challenges of radiotherapy for treating cancer.

Authors:  Dörthe Schaue; William H McBride
Journal:  Nat Rev Clin Oncol       Date:  2015-06-30       Impact factor: 66.675

3.  Radiation induced chromatin conformation changes analysed by fluorescent localization microscopy, statistical physics, and graph theory.

Authors:  Yang Zhang; Gabriell Máté; Patrick Müller; Sabina Hillebrandt; Matthias Krufczik; Margund Bach; Rainer Kaufmann; Michael Hausmann; Dieter W Heermann
Journal:  PLoS One       Date:  2015-06-04       Impact factor: 3.240

4.  ATM alters the otherwise robust chromatin mobility at sites of DNA double-strand breaks (DSBs) in human cells.

Authors:  Annabelle Becker; Marco Durante; Gisela Taucher-Scholz; Burkhard Jakob
Journal:  PLoS One       Date:  2014-03-20       Impact factor: 3.240

5.  Chromosome territories reposition during DNA damage-repair response.

Authors:  Ishita S Mehta; Mugdha Kulashreshtha; Sandeep Chakraborty; Ullas Kolthur-Seetharam; Basuthkar J Rao
Journal:  Genome Biol       Date:  2013-12-13       Impact factor: 13.583

6.  Effect of gadolinium-based nanoparticles on nuclear DNA damage and repair in glioblastoma tumor cells.

Authors:  Lenka Štefančíková; Sandrine Lacombe; Daniela Salado; Erika Porcel; Eva Pagáčová; Olivier Tillement; François Lux; Daniel Depeš; Stanislav Kozubek; Martin Falk
Journal:  J Nanobiotechnology       Date:  2016-07-28       Impact factor: 10.435

7.  Challenges and Contradictions of Metal Nano-Particle Applications for Radio-Sensitivity Enhancement in Cancer Therapy.

Authors:  Eva Pagáčová; Lenka Štefančíková; Franz Schmidt-Kaler; Georg Hildenbrand; Tomáš Vičar; Daniel Depeš; Jin-Ho Lee; Felix Bestvater; Sandrine Lacombe; Erika Porcel; Stéphane Roux; Frederik Wenz; Olga Kopečná; Iva Falková; Michael Hausmann; Martin Falk
Journal:  Int J Mol Sci       Date:  2019-01-30       Impact factor: 5.923

8.  In Vitro Comparison of Passive and Active Clinical Proton Beams.

Authors:  Anna Michaelidesová; Jana Vachelová; Jana Klementová; Tomáš Urban; Kateřina Pachnerová Brabcová; Stanislav Kaczor; Martin Falk; Iva Falková; Daniel Depeš; Vladimír Vondráček; Marie Davídková
Journal:  Int J Mol Sci       Date:  2020-08-06       Impact factor: 5.923

9.  Elucidation of the Clustered Nano-Architecture of Radiation-Induced DNA Damage Sites and Surrounding Chromatin in Cancer Cells: A Single Molecule Localization Microscopy Approach.

Authors:  Michael Hausmann; Martin Falk; Charlotte Neitzel; Andreas Hofmann; Abin Biswas; Theresa Gier; Iva Falkova; Dieter W Heermann; Georg Hildenbrand
Journal:  Int J Mol Sci       Date:  2021-03-31       Impact factor: 5.923

10.  Incorporation of Low Concentrations of Gold Nanoparticles: Complex Effects on Radiation Response and Fate of Cancer Cells.

Authors:  Lucie Dobešová; Theresa Gier; Olga Kopečná; Eva Pagáčová; Tomáš Vičar; Felix Bestvater; Jiří Toufar; Alena Bačíková; Pavel Kopel; Radek Fedr; Georg Hildenbrand; Iva Falková; Martin Falk; Michael Hausmann
Journal:  Pharmaceutics       Date:  2022-01-11       Impact factor: 6.321
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.