Literature DB >> 23413919

Total synthesis of cladoniamide G.

Benjamin C Loosley1, Raymond J Andersen, Gregory R Dake.   

Abstract

The total synthesis of cladoniamide G, a cytotoxic compound against MCF-7 breast cancer cells (10 μg/mL), was accomplished. Key steps in the sequence include oxidative dimerization of 3-acetoxy-5-chloroindole and a tandem process incorporating three steps: bimolecular carbonyl addition, lactam formation, and carbamate removal.

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Year:  2013        PMID： 23413919     DOI： 10.1021/ol400055v

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Reconstruction of cladoniamide biosynthesis reveals nonenzymatic routes to bisindole diversity.

Authors:  Yi-Ling Du; David E Williams; Brian O Patrick; Raymond J Andersen; Katherine S Ryan
Journal:  ACS Chem Biol       Date:  2014-10-24       Impact factor: 5.100

2.  Biocontrol potential and antifungal mechanism of a novel Streptomyces sichuanensis against Fusarium oxysporum f. sp. cubense tropical race 4 in vitro and in vivo.

Authors:  Dengfeng Qi; Liangping Zou; Dengbo Zhou; Miaoyi Zhang; Yongzan Wei; Kai Li; Yankun Zhao; Lu Zhang; Jianghui Xie
Journal:  Appl Microbiol Biotechnol       Date:  2022-02-10       Impact factor: 4.813

3.  Radical-mediated dehydrative preparation of cyclic imides using (NH4)2S2O8-DMSO: application to the synthesis of vernakalant.

Authors:  Dnyaneshwar N Garad; Subhash D Tanpure; Santosh B Mhaske
Journal:  Beilstein J Org Chem       Date:  2015-06-12       Impact factor: 2.883

4.  Mutations in the proteolipid subunits of the vacuolar H+-ATPase provide resistance to indolotryptoline natural products.

Authors:  Fang-Yuan Chang; Shigehiro A Kawashima; Sean F Brady
Journal:  Biochemistry       Date:  2014-10-31       Impact factor: 3.162

5.  Phosphoric acid-catalyzed atroposelective construction of axially chiral arylpyrroles.

Authors:  Lei Zhang; Shao-Hua Xiang; Jun Joelle Wang; Jian Xiao; Jun-Qi Wang; Bin Tan
Journal:  Nat Commun       Date:  2019-02-04       Impact factor: 14.919

6.  Convenient construction of tetrahydrochromeno[4',3':2,3]indolizino[8,7-b]indoles and tetrahydroindolizino[8,7-b]indoles via one-pot domino reaction.

Authors:  Jing Sun; Wang Jiang; Chao-Guo Yan
Journal:  RSC Adv       Date:  2018-08-14       Impact factor: 3.361
  6 in total

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