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Literature DB >> 23413880

Chimeric Ply187 endolysin kills Staphylococcus aureus more effectively than the parental enzyme.

Jinzhe Mao¹, Mathias Schmelcher, William J Harty, Juli Foster-Frey, David M Donovan.

Abstract

Peptidoglycan hydrolases are an effective new source of antimicrobials. A chimeric fusion protein of the Ply187 endopeptidase domain and LysK SH3b cell wall-binding domain is a potent agent against Staphylococcus aureus in four functional assays.

Entities: CellLine Chemical Disease Gene Species

Mesh：

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Year: 2013 PMID： 23413880 PMCID： PMC3690576 DOI： 10.1111/1574-6968.12104

Source DB: PubMed Journal: FEMS Microbiol Lett ISSN： 0378-1097 Impact factor: 2.742

23 in total

1. The recombinant phage lysin LysK has a broad spectrum of lytic activity against clinically relevant staphylococci, including methicillin-resistant Staphylococcus aureus.

Authors: S O'Flaherty; A Coffey; W Meaney; G F Fitzgerald; R P Ross
Journal: J Bacteriol Date: 2005-10 Impact factor: 3.490

Review 2. Bacteriophage endolysins--current state of research and applications.

Authors: Martin J Loessner
Journal: Curr Opin Microbiol Date: 2005-08 Impact factor: 7.934

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Authors: E Díaz; R López; J L García
Journal: Proc Natl Acad Sci U S A Date: 1990-10 Impact factor: 11.205

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Authors: R López; E García; P García; J L García
Journal: Microb Drug Resist Date: 1997 Impact factor: 3.431

5. Target cell specificity of a bacteriocin molecule: a C-terminal signal directs lysostaphin to the cell wall of Staphylococcus aureus.

Authors: T Baba; O Schneewind
Journal: EMBO J Date: 1996-09-16 Impact factor: 11.598

6. Chimeric pneumococcal cell wall lytic enzymes reveal important physiological and evolutionary traits.

Authors: E Diaz; R López; J L Garcia
Journal: J Biol Chem Date: 1991-03-25 Impact factor: 5.157

7. Evidence for a holin-like protein gene fully embedded out of frame in the endolysin gene of Staphylococcus aureus bacteriophage 187.

Authors: M J Loessner; S Gaeng; S Scherer
Journal: J Bacteriol Date: 1999-08 Impact factor: 3.490

Review 8. Bacteriophage lytic enzymes: novel anti-infectives.

Authors: Vincent A Fischetti
Journal: Trends Microbiol Date: 2005-10 Impact factor: 17.079

9. Analysis of the catalytic domain of the lysin of the lactococcal bacteriophage Tuc2009 by chimeric gene assembling.

Authors: M M Sheehan; J L García; R López; P García
Journal: FEMS Microbiol Lett Date: 1996-06-15 Impact factor: 2.742

10. Interchange of functional domains switches enzyme specificity: construction of a chimeric pneumococcal-clostridial cell wall lytic enzyme.

Authors: C Croux; C Ronda; R López; J L García
Journal: Mol Microbiol Date: 1993-09 Impact factor: 3.501

35 in total

1. Identification of Peptidoglycan Hydrolase Constructs with Synergistic Staphylolytic Activity in Cow's Milk.

Authors: Carolin T Verbree; Steven M Dätwyler; Susanne Meile; Fritz Eichenseher; David M Donovan; Martin J Loessner; Mathias Schmelcher
Journal: Appl Environ Microbiol Date: 2017-03-17 Impact factor: 4.792

Review 2. Recombinant Endolysins as Potential Therapeutics against Antibiotic-Resistant Staphylococcus aureus: Current Status of Research and Novel Delivery Strategies.

Authors: Hamed Haddad Kashani; Mathias Schmelcher; Hamed Sabzalipoor; Elahe Seyed Hosseini; Rezvan Moniri
Journal: Clin Microbiol Rev Date: 2017-11-29 Impact factor: 26.132

3. Molecular dissection of phage lysin PlySs2: integrity of the catalytic and cell wall binding domains is essential for its broad lytic activity.

Authors: Yanling Huang; Hang Yang; Junping Yu; Hongping Wei
Journal: Virol Sin Date: 2015-02-04 Impact factor: 4.327

4. Role of SH3b binding domain in a natural deletion mutant of Kayvirus endolysin LysF1 with a broad range of lytic activity.

Authors: Martin Benešík; Jiří Nováček; Lubomír Janda; Radka Dopitová; Markéta Pernisová; Kateřina Melková; Lenka Tišáková; Jiří Doškař; Lukáš Žídek; Jan Hejátko; Roman Pantůček
Journal: Virus Genes Date: 2017-08-29 Impact factor: 2.332

5. Corrected and Republished from: Identification of Peptidoglycan Hydrolase Constructs with Synergistic Staphylolytic Activity in Cow's Milk.

6. Discovery of novel S. aureus autolysins and molecular engineering to enhance bacteriolytic activity.

Authors: Daniel C Osipovitch; Sophie Therrien; Karl E Griswold
Journal: Appl Microbiol Biotechnol Date: 2015-02-18 Impact factor: 4.813

Review 7. Therapeutics and delivery vehicles for local treatment of osteomyelitis.

Authors: Leah H Cobb; Emily M McCabe; Lauren B Priddy
Journal: J Orthop Res Date: 2020-04-21 Impact factor: 3.494

8. Intravitreal injection of the chimeric phage endolysin Ply187 protects mice from Staphylococcus aureus endophthalmitis.

Authors: Pawan Kumar Singh; David M Donovan; Ashok Kumar
Journal: Antimicrob Agents Chemother Date: 2014-06-02 Impact factor: 5.191

Review 9. Antimicrobial bacteriophage-derived proteins and therapeutic applications.

Authors: Dwayne R Roach; David M Donovan
Journal: Bacteriophage Date: 2015-06-23

10. Novel chimeric lysin with high-level antimicrobial activity against methicillin-resistant Staphylococcus aureus in vitro and in vivo.

Authors: Hang Yang; Yun Zhang; Junping Yu; Yanling Huang; Xian-En Zhang; Hongping Wei
Journal: Antimicrob Agents Chemother Date: 2013-11-04 Impact factor: 5.191