Coumarins and a naphthyl labdanoate diarabinoside from the fruits of Peucedanum grande C. B. Clarke.

Phytochemical investigations of the methanolic extract of the fruits of Peucedanum grande C. B. Clarke (Apiaceae) led to the identification of three coumarins and a naphthyl labdanoate diarabinoside characterized as 5-hydroxy-6-isopranyl coumarin (1), 5,6-furanocoumarin (2), 7-methoxy-5,6-furanocoumarin (3), and labdanyl-3alpha-ol-18-(3'"-methoxy-2"'-naphthyl-oate)-3alpha-L-arabinofuranosyl-(2'-->1")-alpha-L-arabinofuranoside (4). The structures of these compounds were identified on the basis of spectral data analysis and chemical reactions. The methanolic extract and 4 showed nephroprotective activity against gentamicin-induced nephrotoxicity in Wistar rats.