Literature DB >> 23413554

Cucurbitane-type triterpenoids from the fruit pulp of Momordica charantia.

Yun-Wen Liao1, Chiy-Rong Chen, Yueh-Hsiung Kuo, Jue-Liang Hsu, Wen-Ling Shih, Hsueh-Ling Cheng, Tzou-Chi Huang, Chi-I Chang.   

Abstract

Three new cucurbitane-type triterpenoids, 5beta,19-epoxy-23(R)-methoxycucurbita-6,24-dien-3beta-ol (1), 5beta,19-epoxy-23(S)-methoxycucurbita-6,24-dien-3beta-ol (2), and 3beta-hydroxy-23(R)-methoxycucurbita-6,24-dien-5beta,19-olide (3), were isolated from the fruit pulp of Momordica charantia. Their structures were established on the basis of extensive NMR (1H, 13C, COSY, HMQC, HMBC, and NOESY) and EI-MS studies. Compound 1 exhibited cytotoxic activity against the SK-Hep 1 cell line.

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Year:  2012        PMID： 23413554

Source DB:  PubMed          Journal:  Nat Prod Commun        ISSN： 1555-9475            Impact factor:   0.986


  2 in total

1.  Four new cucurbitane-type triterpenes from Momordica charantia L. with their cytotoxic activities and protective effects on H2O2-damaged pancreatic cells.

Authors:  Jiayin Yue; Yuanyuan Sun; Jing Xu; Xiaoshu Zhang; Yuqing Zhao
Journal:  J Nat Med       Date:  2019-06-29       Impact factor: 2.343

2.  Investigation of cell cytotoxic activity and molecular mechanism of 5β,19-epoxycucurbita-6,23(E)-diene-3β,19(R),25-triol isolated from Momordica charantia on hepatoma cells.

Authors:  Mei-Kang Yuan; Ju-Wen Kao; Wen-Tung Wu; Chiy-Rong Chen; Chi-I Chang; Yu-Jen Wu
Journal:  Pharm Biol       Date:  2022-12       Impact factor: 3.889
  2 in total

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