Literature DB >> 23413285

The effect of high-intensity aerobic interval training on postinfarction left ventricular remodelling.

Richard Godfrey1, Thomas Theologou, Santo Dellegrottaglie, Sukumaran Binukrishnan, Jay Wright, Gregory Whyte, Georgina Ellison.   

Abstract

This is the third in a series of case studies on an individual with normal coronaries who sustained an idiopathic acute myocardial infarction . Bilateral pulmonary emboli almost 2 years post-myocardial infarction (MI) revealed coagulopathy as the cause. The original MI resulted in 16% myocardial scar tissue. An increasing number of patients are surviving MI, hence the burden for healthcare often shifts to heart failure. Accumulating evidence suggests high-intensity aerobic interval exercise (AHIT) is efficacious in improving cardiac function in health and disease. However, its impact on MI scar has never been assessed. Accordingly, the 50-year-old subject of this case study undertook 60 weeks of regular AHIT. Successive cardiac MRI results demonstrate, for the first time, a decrease in MI scar with exercise and, alongside mounting evidence of high efficacy and low risk, suggests AHIT may be increasingly important in future prevention and reversing of disease and or amelioration of symptoms.

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Year:  2013        PMID: 23413285      PMCID: PMC3604414          DOI: 10.1136/bcr-2012-007668

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  25 in total

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Review 3.  Resident cardiac stem cells.

Authors:  D Torella; G M Ellison; I Karakikes; B Nadal-Ginard
Journal:  Cell Mol Life Sci       Date:  2007-03       Impact factor: 9.261

4.  Response to letter regarding article, "Cardiovascular risk of high- versus moderate-intensity aerobic exercise in coronary heart disease patients".

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5.  Endogenous cardiac stem cell activation by insulin-like growth factor-1/hepatocyte growth factor intracoronary injection fosters survival and regeneration of the infarcted pig heart.

Authors:  Georgina M Ellison; Daniele Torella; Santo Dellegrottaglie; Claudia Perez-Martinez; Armando Perez de Prado; Carla Vicinanza; Saranya Purushothaman; Valentina Galuppo; Claudio Iaconetti; Cheryl D Waring; Andrew Smith; Michele Torella; Carlos Cuellas Ramon; Jose Manuel Gonzalo-Orden; Valter Agosti; Ciro Indolfi; Manuel Galiñanes; Felipe Fernandez-Vazquez; Bernardo Nadal-Ginard
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Authors:  B Nadal-Ginard
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Authors:  J van der Velden; D Merkus; B R Klarenbeek; A T James; N M Boontje; D H W Dekkers; G J M Stienen; J M J Lamers; D J Duncker
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Authors:  S N Blair; H W Kohl; R S Paffenbarger; D G Clark; K H Cooper; L W Gibbons
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10.  Early exercise training normalizes myofilament function and attenuates left ventricular pump dysfunction in mice with a large myocardial infarction.

Authors:  Monique C de Waard; Jolanda van der Velden; Virginie Bito; Semir Ozdemir; Liesbeth Biesmans; Nicky M Boontje; Dick H W Dekkers; Kees Schoonderwoerd; Hans C H Schuurbiers; Rini de Crom; Ger J M Stienen; Karin R Sipido; Jos M J Lamers; Dirk J Duncker
Journal:  Circ Res       Date:  2007-03-08       Impact factor: 17.367

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Review 2.  Sirtuin regulation in aging and injury.

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Journal:  Biochim Biophys Acta       Date:  2015-08-21

3.  High-intensity interval training improves metabolic syndrome and body composition in outpatient cardiac rehabilitation patients with myocardial infarction.

Authors:  Yaoshan Dun; Randal J Thomas; Joshua R Smith; Jose R Medina-Inojosa; Ray W Squires; Amanda R Bonikowske; Hsuhang Huang; Suixin Liu; Thomas P Olson
Journal:  Cardiovasc Diabetol       Date:  2019-08-14       Impact factor: 9.951

  3 in total

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