| Literature DB >> 23412111 |
Lucía D Garza-García1, Leydi M Carrillo-Cocom, Diana Araiz-Hernández, Pedro Soto-Vázquez, Julián López-Meza, Eduardo J Tapia-Mejía, Sergio Camacho-León, Erika García-López, Ciro A Rodríguez-González, Mario M Alvarez.
Abstract
We report a proof-of-principle for the use of micro-devices as continuous bioreactors for the production of monoclonal antibodies. We culture CHO cells on the surface of PMMA "zigzag" channels textured with semi-spherical cavities coated with fibronectin, observing steady-state productivities 100 times higher than those observed in full scale systems.Entities:
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Year: 2013 PMID： 23412111 DOI： 10.1039/c3lc50104c
Source DB: PubMed Journal: Lab Chip ISSN： 1473-0189 Impact factor: 6.799